Corberand J, Benchekroun S, Nguyen F, Laharrague P, Pris J
Cancer Res. 1982 Apr;42(4):1595-9.
Five tests investigating different aspects of the nonspecific defense mechanisms including capillary tube random migration, particle ingestion activity, quantitative and histochemical nitroblue tetrazolium dye reduction by polymorphonuclear neutrophils, and serum lysozyme concentrations were performed in 46 patients with Hodgkin's disease. The anomalies observed in the active stage of the disease consisted of a decreased random migration, a high level of serum lysozyme, and an increased nitroblue tetrazolium reduction by resting phagocytes associated with a decrease in nitroblue tetrazolium reduction by stimulated phagocytes. The particle ingestion activity was normal. The serum lysozyme assay was the only test observed to normalize in the group of patients in remission. Its determination, therefore, offers an additional means of evaluating disease activity.
对46例霍奇金病患者进行了五项测试，以研究非特异性防御机制的不同方面，包括毛细管随机迁移、颗粒摄取活性、多形核中性粒细胞对定量和组织化学硝基蓝四氮唑染料的还原，以及血清溶菌酶浓度。在疾病活动期观察到的异常包括随机迁移减少、血清溶菌酶水平升高、静息吞噬细胞对硝基蓝四氮唑的还原增加，同时刺激吞噬细胞对硝基蓝四氮唑的还原减少。颗粒摄取活性正常。血清溶菌酶测定是唯一一项在缓解期患者组中观察到恢复正常的测试。因此，其测定为评估疾病活动提供了一种额外的方法。
