DeVore D T
Oral Surg Oral Med Oral Pathol. 1977 May;43(5):677-86. doi: 10.1016/0030-4220(77)90050-0.
Collagen was extracted with acid from fresh calf skin, reconstituted and crosslinked with one of four aldehydes, and implanted into surgically created defects in rabbit mandibles. All grafts were histocompatible, with no signs of infection or rejection. There was partial degradation of simple aldehyde cross-linked collagen grafts, with new bone formation evident throughout as early as 4 weeks and complete by 3 to 4 months. The greater the degree of aldehyde-induced cross-linking, the longer the time of degradation, with dialdehyde-fixed specimens not starting to degrade for 6 months and highly cross-linked grafts intact and stable after 1 year. In grafted animals the mandible regained its original contour, while in control animals a defect remained after 1 year.
从新鲜小牛皮肤中用酸提取胶原蛋白，进行重构并用四种醛类之一进行交联，然后植入兔子下颌骨的手术创口处。所有移植物都具有组织相容性，没有感染或排斥的迹象。简单醛交联胶原蛋白移植物有部分降解，早在4周时就可见到新骨形成，到3至4个月时完全形成。醛诱导交联程度越高，降解时间越长，二醛固定的标本6个月才开始降解，高度交联的移植物1年后仍保持完整和稳定。在接受移植的动物中，下颌骨恢复了原来的轮廓，而在对照动物中，1年后仍有缺损。
