Niedermayer Fiona, Rospleszcz Susanne, Matthiessen Clara, Hoffmann Barbara, Stoecklein Sophia, Haueise Tobias, Norajitra Tobias, Schlett Christopher L, Nattenmüller Johanna, Bamberg Fabian, Machann Jürgen, Günther Matthias, Hirsch Jochen, Nagrani Rajini, Völzke Henry, Meinke-Franze Claudia, Hosten Norbert, Nonnenmacher Tobias, Budai Bettina Katalin, Palm Viktoria, Katzke Verena, Greiser Karin Halina, Schulz-Menger Jeanette, Niendorf Thoralf, Endemann Beate, Pischon Tobias, Staab Jeroen, Dallavalle Marco, Schneider Alexandra, Wolf Kathrin, Peters Annette
Chair of Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-Universität Munich, Munich, Germany; Institute of Epidemiology, Helmholtz Zentrum München (GmbH), German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München (GmbH), German Research Center for Environmental Health, Neuherberg, Germany; Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Freiburg, Germany.
Environ Int. 2025 Jul;201:109566. doi: 10.1016/j.envint.2025.109566. Epub 2025 May 28.
Little is known about the relation between traffic noise exposure, an established environmental risk factor for cardiovascular disease, and early obesity-related risk markers such as adipose tissue (AT) and hepatic fat. Therefore, we aimed to assess associations of long-term road traffic noise exposure with AT depots measures from whole-body magnetic resonance imaging (MRI). We analyzed cross-sectional data from 11,343 participants from the population-based German National Cohort (NAKO) who underwent MRI examination between 2014 and 2016, considering visceral (VAT), subcutaneous abdominal (SCAAT), subcutaneous thoracic AT (SCTAT) and hepatic fat content as outcomes. Annual road traffic noise (L) data from the year 2017 (source: central EIONET data repository) was used to calculate weighted mean noise levels on a continuous scale within 10 and 100-meter buffers of participants' residencies. Among 11,101 participants with complete outcome data, 48.7 % were women, and the mean age was 51.9 years. Higher annual L was associated with increased AT depots and hepatic fat content in men (e.g., VAT: 1.72 %-change [95 % confidence interval: [0.14 %; 3.30 %]; SCAAT: 2.18 %-change [0.43 %; 3.93 %], hepatic fat content: 3.57 %-change [1.41 %; 5.78 %] per 10 dB(A) increase in L (10 m)) and women (e.g., VAT: 3.13 %-change [1.09 %; 5.18 %]; SCAAT: 2.38 %-change [0.55 %; 4.20 %], hepatic fat content: 3.08 %-change [1.00 %; 5.21 %] per 10 dB(A) increase in L (10 m)). Associations were robust with all outcomes after adjusting for air pollutants and surrounding greenness, and effect modification by obesity and hypertension was observed for SCAAT, SCTAT and hepatic fat content. Our findings indicate that annual exposure to road traffic noise is associated with increased adipose tissue depots and hepatic fat content, and thus present novel evidence for the cross-sectional association between noise and early MRI-derived metabolic health markers.
交通噪声暴露是一种已确定的心血管疾病环境风险因素，而关于它与早期肥胖相关风险标志物（如脂肪组织（AT）和肝脏脂肪）之间的关系，人们所知甚少。因此，我们旨在评估长期道路交通噪声暴露与全身磁共振成像（MRI）测量的AT储存之间的关联。我们分析了来自基于人群的德国国民队列（NAKO）的11343名参与者的横断面数据，这些参与者在2014年至2016年期间接受了MRI检查，将内脏脂肪（VAT）、腹部皮下脂肪（SCAAT）、胸部皮下AT（SCTAT）和肝脏脂肪含量作为观察指标。使用2017年的年度道路交通噪声（L）数据（来源：欧洲环境信息和观测网络（EIONET）中央数据存储库）来计算参与者住所10米和100米缓冲区内连续尺度上的加权平均噪声水平。在11101名有完整观察指标数据的参与者中，48.7%为女性，平均年龄为51.9岁。较高的年度L与男性的AT储存和肝脏脂肪含量增加相关（例如，每10分贝（A）的L增加（10米），VAT：变化1.72%[95%置信区间：[0.14%；3.30%]；SCAAT：变化2.18%[0.43%；3.93%]，肝脏脂肪含量：变化3.57%[1.41%；5.78%]）以及女性（例如，每10分贝（A）的L增加（10米），VAT：变化3.13%[1.09%；5.18%]；SCAAT：变化2.38%[0.55%；4.20%]，肝脏脂肪含量：变化3.08%[1.00%；5.21%]）。在调整空气污染物和周围绿化情况后，所有观察指标的关联都很稳健，并且在SCAAT、SCTAT和肝脏脂肪含量方面观察到肥胖和高血压的效应修正。我们的研究结果表明，年度道路交通噪声暴露与脂肪组织储存和肝脏脂肪含量增加相关，从而为噪声与早期MRI衍生的代谢健康标志物之间的横断面关联提供了新的证据。
