Marzouk Nour H, Rashwan Hannah H, El-Hadidi Mohamed, Ramadan Raghda, Mysara Mohamed
Bioinformatics Group, Centre for Informatics Science (CIS), School of Information Technology and Computer Science (ITCS), Nile University, Giza, Egypt.
Cancer and Genomic Sciences, School of Medical Sciences, College of Medicine and Health (CME), University of Birmingham Dubai, Dubai, United Arab Emirates.
NPJ Parkinsons Dis. 2025 Jun 3;11(1):145. doi: 10.1038/s41531-025-00950-z.
Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by motor dysfunction coupled with gastrointestinal disturbances. Recent studies implicate the gut microbiome with the development of PD, yet pinpointing the exact microbial players is still to be determined. This meta-analysis is the first to consolidate five homogenous case-control studies, covering the same variable regions of the 16S rRNA of 1007 fecal samples. Utilizing our unified pipeline, we identified several key players potentially contributing to PD. Our findings reveal higher microbial diversity characterized by elevated levels GABA consuming species particularly Evtepia gabavorous, contributing to neuronal excitability. We also report the abundance of the proinflammatory Klebsiella variicola and the HS-producing Streptococcus anginosus bacteria, potentially promoting α-synuclein accumulation in the brain. This comprehensive analysis highlights the potential of gut microbiota as a biomarker and a therapeutic strategy to mitigate the progression of PD, possibly facilitating diagnosis and enhancing patient outcomes.
帕金森病（PD）是第二常见的神经退行性疾病，其特征是运动功能障碍并伴有胃肠道紊乱。最近的研究表明肠道微生物群与帕金森病的发展有关，但确定确切的微生物因素仍有待确定。这项荟萃分析首次整合了五项同类病例对照研究，涵盖了1007份粪便样本16S rRNA的相同可变区域。利用我们统一的流程，我们确定了几个可能导致帕金森病的关键因素。我们的研究结果显示，以消耗γ-氨基丁酸（GABA）的物种（特别是嗜GABA埃希菌）水平升高为特征的微生物多样性更高，这会导致神经元兴奋性增加。我们还报告了促炎性变异克雷伯菌和产硫化氢的咽峡炎链球菌的丰度，它们可能会促进α-突触核蛋白在大脑中的积累。这项全面分析突出了肠道微生物群作为一种生物标志物和减轻帕金森病进展的治疗策略的潜力，可能有助于诊断并改善患者预后。
