Tsuburaya H, Watanabe I, Takahashi M, Endo S
Jpn J Antibiot. 1985 Jun;38(6):1509-15.
Penetration of aspoxicillin (ASPC), a new semisynthetic penicillin of broad spectrum, into normal and cancer tissue and wound exudate were examined in breast cancer. ASPC was administered by single injection of 1 or 2 g. The concentration of ASPC in the resected skin, normal mammary gland and cancer were similar to their serum levels, when ASPC was administered before radical mastectomy. ASPC concentration in the wound exudate which was collected from the inserted drains into the resected area reached the maximum at 3 approximately 4 hours after the injection at the levels of 19.4 micrograms/ml (1 g) and 35.1 micrograms/ml (2 g). The level decreased gradually by maintained still high at 3.7 micrograms/ml (1 g) and 11.4 micrograms/ml (2 g) even 8 hours after the injection. From these results it may be expected that ASPC is a useful penicillin in the breast surgery.
在乳腺癌患者中，研究了新型半合成广谱青霉素阿扑西林（ASPC）在正常组织、癌组织及伤口渗出液中的渗透情况。单次注射1克或2克阿扑西林。在根治性乳房切除术前给予阿扑西林时，切除皮肤、正常乳腺组织和癌组织中阿扑西林的浓度与其血清水平相似。从插入切除区域引流管收集的伤口渗出液中，阿扑西林浓度在注射后3至4小时达到最高，分别为19.4微克/毫升（1克剂量）和35.1微克/毫升（2克剂量）。即使在注射8小时后，该水平仍逐渐下降，但仍维持在较高水平，分别为3.7微克/毫升（1克剂量）和11.4微克/毫升（2克剂量）。从这些结果可以预期，阿扑西林在乳腺手术中是一种有用的青霉素。
