Kobayashi T, Yayoi E, Naoi M, Mori T
Jpn J Antibiot. 1984 Sep;37(9):1647-51.
In order to demonstrate the distribution of an antibiotic to normal breast tissues and its penetration into the axillary wound exudate, 1 g of a new cephem antibiotic, cefotiam (CTM), was infused intravenously over 1 hour in 14 patients with breast cancer before and after mastectomy. CTM concentrations were assayed by the cylinder-plate method, using Proteus mirabilis ATCC 21100 as the test organism. Overall CTM levels in the normal breast tissues ranged from 3.6 to 27.7 micrograms/g, and 5.2 micrograms/g of CTM still remained 170 minutes after administration. No significant differences were found in CTM levels of 3 parts of the breast tissue from the same patient. Serum CTM levels rapidly declined after the end of infusion of CTM. Concentrations of CTM in axillary wound exudate after mastectomy ranged from 5.2 to 13.6 micrograms/ml at 3 hours after administration and were almost undetectable at 24 hours. It is concluded that CTM levels in breast tissues were almost the same as those in other tissues.
为了证明一种抗生素在正常乳腺组织中的分布及其向腋窝伤口渗出液中的渗透情况，在14例乳腺癌患者乳房切除术前和术后，将1克新型头孢烯抗生素头孢替安（CTM）在1小时内静脉输注。采用奇异变形杆菌ATCC 21100作为测试菌，通过圆筒平板法测定CTM浓度。正常乳腺组织中的CTM总体水平在3.6至27.7微克/克之间，给药后170分钟仍有5.2微克/克的CTM残留。同一患者乳腺组织3个部位的CTM水平未发现显著差异。CTM输注结束后，血清CTM水平迅速下降。乳房切除术后3小时，腋窝伤口渗出液中CTM浓度在5.2至13.6微克/毫升之间，24小时时几乎检测不到。结论是乳腺组织中的CTM水平与其他组织中的水平几乎相同。
