Hashimoto I, Sawada Y, Nakamura T, Mikami J, Nishindai H, Yoshimoto M, Nakanishi Y, Fugono T, Maeda K
Jpn J Antibiot. 1986 Jan;39(1):99-108.
Cefotiam (CTM) in a dose of 2 g was given by intravenous bolus injection to 16 patients with breast cancer operated upon radical mastectomy with suction drainage. The materials of exudate from drain were taken at intervals by sterilized paper disc and determined by the paper disc method with Proteus mirabilis ATCC 21100 as the test organism to CTM concentrations. CTM concentrations in exudate from suction drain of patients increased quickly after intravenous injection, and reached to peak early time on 2 to 3 days after operation. While on 6 days after operation, the CTM concentrations were comparatively lower and reached to peak at 2 approximately 3 hours after injection. The CTM concentrations in exudate exceed the antibacterial levels of CTM and are thought to be sufficient to produce prophylactic effects in the operation.
对16例行根治性乳房切除术并行负压引流的乳腺癌患者静脉推注2g头孢替安（CTM）。用无菌纸盘定期采集引流液样本，以奇异变形杆菌ATCC 21100为测试菌，采用纸盘法测定引流液中CTM的浓度。静脉注射后，患者负压引流液中的CTM浓度迅速升高，术后2至3天较早达到峰值。而术后6天时，CTM浓度相对较低，注射后约2至3小时达到峰值。引流液中的CTM浓度超过了CTM的抗菌水平，被认为足以在手术中产生预防效果。
