Owu Ruth T, Annan Efua E, Ainuson-Quampah Joana, Asante Matilda, Brown Charles Addoquaye, Asare George A
Department of Dietetics, University of Ghana, Accra, Ghana.
Department of Medical Laboratory Sciences, University of Ghana, Accra, Ghana.
J Nutr Metab. 2025 May 27;2025:8602969. doi: 10.1155/jnme/8602969. eCollection 2025.
Previous research on sweeteners' effect on health has focused on indices of cardiometabolic risk factors without considering lipid ratios such as the Atherogenic Index of Plasma (AIP) and Castelli Risk Index I and II (CRI-I and CRI-II). The study sought to evaluate the effect of natural sweeteners on lipid profiles and lipid ratios. Seventy-eight female Sprague Dawley rats (6 rats per group) were administered with different doses of sweeteners (3 groups per sweetener): white sugar (0.035 g/mL, 0.07 g/mL, and 0.1 g/mL), brown sugar (0.036 g/mL, 0.072 g/mL, and 0.11 g/mL), honey (0.047 g/mL, 0.094 g/mL, and 0.14 g/mL) and stevia (0.004 g/mL, 0.014 g/mL, and 0.021 g/mL) for 17 weeks. The highest weight gain was observed with high-dose stevia administration (72.7 g ± 10.5). The group administered with high dose of white sugar had the highest CRI-I (1.79 ± 0.11) and CRI-II (0.49 ± 0.09). CRI-I and CRI-II had a dose-dependent increase with white sugar. The AIP was highest in the high-dose stevia group (0.21 ± 0.07) with dose-dependent increases within the stevia group. High intakes of white sugar and stevia tend to promote the development or progression of atherosclerosis.
先前关于甜味剂对健康影响的研究主要集中在心血管代谢风险因素指标上，而未考虑诸如血浆致动脉粥样硬化指数（AIP）以及卡斯泰利风险指数I和II（CRI-I和CRI-II）等血脂比率。该研究旨在评估天然甜味剂对血脂谱和血脂比率的影响。将78只雌性斯普拉格-道利大鼠（每组6只大鼠）给予不同剂量的甜味剂（每种甜味剂3组）：白糖（0.035 g/mL、0.07 g/mL和0.1 g/mL）、红糖（0.036 g/mL、0.072 g/mL和0.11 g/mL）、蜂蜜（0.047 g/mL、0.094 g/mL和0.14 g/mL）以及甜菊糖（0.004 g/mL、0.014 g/mL和0.021 g/mL），持续17周。高剂量甜菊糖给药组观察到最高体重增加（72.7 g±10.5）。高剂量白糖给药组的CRI-I（1.79±0.11）和CRI-II（0.49±0.09）最高。CRI-I和CRI-II随白糖剂量呈剂量依赖性增加。高剂量甜菊糖组的AIP最高（0.21±0.07），且在甜菊糖组内呈剂量依赖性增加。高摄入白糖和甜菊糖往往会促进动脉粥样硬化的发生或发展。
