肥胖对亚裔美国癌症患者新冠病毒病结局的不同影响
Obesity's Disparate Impact on COVID-19 Outcomes in Asian American Patients with Cancer.
作者信息
Nguyen Ryan H, Shah Pankil K, Mishra Sanjay, Fu Julie, Reid Sonya, Hawley Jessica E, Hwang Clara, Singh Sunny R K, Gatson Na Tosha, Florez Narjust, Chism David, Serrano Oscar K, Bashir Babar, Nagaraj Gayathri, Mckay Rana R, Hayes-Lattin Brandon, Koshkin Vadim S, Acoba Jared D, Zamulko Olga, Geiger Christoper L, Warner Jeremy L, Shah Dimpy P, Venepalli Neeta K
机构信息
University of Illinois at Chicago.
University of Texas Health San Antonio.
出版信息
medRxiv. 2025 May 16:2025.05.14.25327577. doi: 10.1101/2025.05.14.25327577.
Data on COVID-19 outcomes in Asian Americans and Pacific Islanders (AAPI) are lacking. We analyzed data from 6,244 patients from the COVID-19 and Cancer Consortium, including 6.0% AAPI patients, to examine disparities in outcomes following acute COVID-19. Despite AAPI patients having lower median BMI than non-Hispanic White (NHW) patients and higher diabetes rates, both groups showed similar 30-day mortality and COVID-19 outcomes. In multivariable analyses, morbid obesity (BMI >35 kg/m) in AAPI patients was associated with significantly higher 30-day mortality (OR 4.96; 95% CI 1.78 - 13.88) and COVID-19 severity (OR 2.6; 95% CI 1.26 - 5.35); underscoring the differential impact of obesity in AAPI patients.
关于亚裔美国人和太平洋岛民（AAPI）感染新冠病毒（COVID-19）的结果数据尚缺。我们分析了来自COVID-19与癌症联盟的6244名患者的数据，其中包括6.0%的AAPI患者，以研究急性COVID-19后结果的差异。尽管AAPI患者的中位体重指数低于非西班牙裔白人（NHW）患者且糖尿病发病率更高，但两组的30天死亡率和COVID-19结果相似。在多变量分析中，AAPI患者的病态肥胖（体重指数>35 kg/m）与显著更高的30天死亡率（比值比4.96；95%置信区间1.78 - 13.88）和COVID-19严重程度（比值比2.6；95%置信区间1.26 - 5.35）相关；这突出了肥胖对AAPI患者的不同影响。
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