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使用新生大鼠模型评估西罗莫司对小儿肺静脉狭窄的治疗效果

Evaluation of Treatment Effect of Sirolimus on Pediatric Pulmonary Vein Stenosis Using a Neonatal Rat Model.

作者信息

Li Debao, Xiao Yingying, Ruan Peisen, Wan Zunmin, Hu Yuqing, Sun Sijuan, Wang Zheng, Zheng Sixie, Yan Yi, Chen Hao, Zhang Hao, Shen Chun, Sun Qi, Ye Lincai

机构信息

Department of Thoracic and Cardiovascular Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Pediatric Surgery, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Department of Thoracic and Cardiovascular Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

JACC Basic Transl Sci. 2025 Jul;10(7):101229. doi: 10.1016/j.jacbts.2025.01.010. Epub 2025 Apr 2.

DOI:10.1016/j.jacbts.2025.01.010
PMID:40464728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12434204/
Abstract

A modified neonatal rat model of pulmonary vein stenosis (PVS) via bilateral pulmonary vein banding was introduced for the first time, providing a platform for understanding the pathophysiology of PVS and developing treatments. In addition, using this model, the mTOR inhibitor sirolimus was evaluated as a treatment for PVS and exhibited significant therapeutic effects, indicating the need for accelerated ethics approval in clinical settings where sirolimus is not yet in use.

摘要

首次引入了一种通过双侧肺静脉结扎建立的改良新生大鼠肺静脉狭窄（PVS）模型，为理解PVS的病理生理学和开发治疗方法提供了一个平台。此外，利用该模型，对mTOR抑制剂西罗莫司作为PVS的治疗方法进行了评估，结果显示出显著的治疗效果，这表明在尚未使用西罗莫司的临床环境中需要加快伦理审批。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/ec8032caee67/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/b040df495749/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/a34b27d74d32/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/90728b1fe5fc/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/63d946ddcfa0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/63b8f89911de/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/0aee63373116/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/ec8032caee67/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/b040df495749/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/a34b27d74d32/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/90728b1fe5fc/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/63d946ddcfa0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/63b8f89911de/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/0aee63373116/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/12434204/ec8032caee67/gr6.jpg

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引用本文的文献

1
Evaluation of Treatment Effect of Sirolimus on Pediatric Pulmonary Vein Stenosis Using a Neonatal Rat Model Induced by Bilateral Pulmonary Vein Banding.使用双侧肺静脉环扎诱导的新生大鼠模型评估西罗莫司对小儿肺静脉狭窄的治疗效果
JACC Basic Transl Sci. 2025 Jul;10(7):101296. doi: 10.1016/j.jacbts.2025.04.010.

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J Vis Exp. 2023 Jun 9(196). doi: 10.3791/65372.
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A neonatal rat model of pulmonary vein stenosis.一种新生儿肺静脉狭窄大鼠模型。
Cell Biosci. 2023 Jun 19;13(1):112. doi: 10.1186/s13578-023-01058-8.
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Pathogenesis, Evaluation, and Management of Pulmonary Vein Stenosis: JACC Review Topic of the Week.肺静脉狭窄的发病机制、评估和管理：JACC 每周综述专题。
J Am Coll Cardiol. 2023 Jun 20;81(24):2361-2373. doi: 10.1016/j.jacc.2023.04.016.
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Targeting the biology of aging with mTOR inhibitors.用 mTOR 抑制剂靶向衰老的生物学。
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