Wu Dongsheng, Wang Tongtong, Wu Haoran, Dong Yuang, Huang Ziqin, Zhang Jun, Zhang Wei
First Clinical Medical College of Anhui University of Traditional Chinese Medicine, Hefei, China.
The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, China.
Front Microbiol. 2025 Jul 28;16:1630924. doi: 10.3389/fmicb.2025.1630924. eCollection 2025.
Influenza (hereinafter referred to as influenza) is a pandemic and seasonal respiratory infectious disease that can lead to a global pandemic, posing a major threat to global public health. Studies have shown that influenza can lead to an imbalance in the intestinal flora, and disruption of the intestinal flora can exacerbate the progression of the disease, suggesting a potential link between influenza and intestinal flora. There is still a lack of systematic summary of bibliometric analysis in this field, therefore, this study aims to reveal the research dynamics, collaborative networks and cutting-edge hotspots in the field of influenza-intestinal flora association through bibliometric methods.
Bibliometric analysis was used to retrieve 554 papers on influenza and intestinal flora from the Web of Science Core Collection (WoSCC) database from 2011 to 2025. After screening, 283 papers were included, and co-occurrence and clustering analyses of countries, authors, institutions, journals, references, and keywords were performed using VOSviewer, CiteSpace, and Bibliometrix; statistical visualization was performed via Microsoft Excel.
China is the country with the highest number of published papers and the leading CSI in terms of international collaboration intensity. The most popular journal in this field is Frontiers in Microbiology with 20 publications, while the most influential journal is Nature with 605 citations. Zhejiang University was the institution with the highest number of publications and Francois Trottein was the most prolific author. Keyword co-occurrence analysis showed that gut microbiota, influenza, probiotics, intestinal microbiota and COVID-19 were the core research hotspots, and clustering analysis further revealed the "intestinal-pulmonary axis of immunoregulation," such as Cluster analysis further revealed the "intestinal-lung axis immunoregulation," such as Th17/Treg balance, short-chain fatty acids and probiotics, as the cutting edge.
This study is the first to systematically map the bibliometrics of influenza and gut flora. The most influential countries, research institutions and researchers were identified through bibliometric analysis, showing the current research trends and hotspots in influenza and intestinal flora control. The results can provide theoretical guidance for future influenza prevention and control strategies targeting flora.
流感（以下简称流感）是一种大流行和季节性呼吸道传染病，可引发全球大流行，对全球公共卫生构成重大威胁。研究表明，流感可导致肠道菌群失衡，而肠道菌群的破坏会加剧疾病进展，提示流感与肠道菌群之间可能存在联系。该领域目前仍缺乏文献计量分析的系统总结，因此，本研究旨在通过文献计量方法揭示流感与肠道菌群关联领域的研究动态、合作网络和前沿热点。
采用文献计量分析方法，从Web of Science核心合集（WoSCC）数据库中检索2011年至2025年关于流感和肠道菌群的554篇论文。经筛选后纳入283篇论文，并使用VOSviewer、CiteSpace和Bibliometrix对国家、作者、机构、期刊、参考文献和关键词进行共现和聚类分析；通过Microsoft Excel进行统计可视化。
中国是发表论文数量最多的国家，在国际合作强度方面居领先地位。该领域最受欢迎的期刊是《微生物学前沿》，发表了20篇论文，而最具影响力的期刊是《自然》，被引次数为605次。浙江大学是发表论文数量最多的机构，弗朗索瓦·特罗特安是发文量最多的作者。关键词共现分析表明，肠道微生物群、流感、益生菌、肠道微生物群和新冠病毒是核心研究热点，聚类分析进一步揭示了“免疫调节的肠 - 肺轴”，如聚类分析进一步揭示了Th17/Treg平衡、短链脂肪酸和益生菌等“肠 - 肺轴免疫调节”作为前沿研究内容。
本研究首次系统绘制了流感与肠道菌群的文献计量图谱。通过文献计量分析确定了最具影响力的国家、研究机构和研究人员，展示了流感和肠道菌群控制方面的当前研究趋势和热点。研究结果可为未来针对菌群的流感防控策略提供理论指导。
