Gentile R D, Donovan D T
Laryngoscope. 1985 Oct;95(10):1161-6. doi: 10.1288/00005537-198510000-00002.
Neurotropic melanoma is a lesion which simulates a cutaneous fibrous tumor whose clinical course is characterized by local infiltration, multiple recurrences, and commonly by metastasis. Like adenoid-cystic tumors of the head and neck, the neurotropic melanoma has a predilection for perineural invasion and extension along peripheral nerves. Its microscopic picture is characterized by atypical "neuroma-like" patterns of Schwann cells and spindle cells, by poorly defined margins, and by neurotropism. Lentigo malignant melanoma (LMM) is a precursory lesion. The neurotropic melanoma is of particular interest to the head and neck surgeon because in the less than 50 reported cases of this rare tumor the preponderant sites were head, neck, and lip. We report two cases of neurotropic melanoma of the head and neck which demonstrate the characteristic perineural invasion of cranial nerves and extension along cranial nerves to the central nervous system. The clinical and pathologic features of the neurotropic melanoma are reviewed and the key diagnostic and therapeutic considerations in these patients are discussed.
亲神经性黑色素瘤是一种类似皮肤纤维瘤的病变，其临床病程以局部浸润、多次复发且通常伴有转移为特征。与头颈部腺样囊性肿瘤一样，亲神经性黑色素瘤倾向于沿神经周围侵犯并沿周围神经扩展。其显微镜下表现的特征为施万细胞和梭形细胞呈现非典型的“神经瘤样”形态、边界不清以及亲神经性。恶性雀斑样黑色素瘤（LMM）是一种前驱病变。亲神经性黑色素瘤对头颈部外科医生尤为重要，因为在报道的不到50例这种罕见肿瘤病例中，主要发病部位是头、颈和唇部。我们报告两例头颈部亲神经性黑色素瘤病例，展示了其沿颅神经侵犯并向中枢神经系统扩展的特征性神经周围侵犯。本文回顾了亲神经性黑色素瘤的临床和病理特征，并讨论了这些患者关键的诊断和治疗要点。
