McGinnis J P, Greer J L, Wolfe N L
J Oral Pathol. 1986 Sep;15(8):445-9. doi: 10.1111/j.1600-0714.1986.tb00655.x.
The neurotropic melanoma is a rare and highly malignant variant of melanoma that possesses a biphasic neoplastic component. A lentigo maligna melanoma commonly precedes a downgrowth of spindle cells that exhibit fascicle formation and striking neurotropism. A strong predilection for occurrence on the lip has been indicated by published reports. Difficulties exist in the initial diagnosis of the tumor because of its biphasic growth pattern, while the biologic behavior of the tumor is that of multiple recurrences, perineural metastases with cranial neuropathies and intracranial disease, and regional and distant organ metastases. The clinical and histopathologic features of a neurotropic melanoma of the lip are shown, and a brief review of the histogenesis, treatment, and prognosis are presented.
嗜神经性黑色素瘤是一种罕见且高度恶性的黑色素瘤变体，具有双相性肿瘤成分。恶性雀斑样痣黑色素瘤通常先于梭形细胞向下生长，梭形细胞表现出束状形成和显著的嗜神经性。已发表的报告表明，该肿瘤强烈倾向于发生在唇部。由于其双相生长模式，肿瘤的初始诊断存在困难，而肿瘤的生物学行为表现为多次复发、伴有颅神经病变和颅内疾病的神经周围转移以及区域和远处器官转移。本文展示了唇部嗜神经性黑色素瘤的临床和组织病理学特征，并对其组织发生、治疗和预后进行了简要综述。
