雌性小鼠对乙醇的敏感性：卵巢切除术和品系的影响。

Sensitivity to ethanol in female mice: effects of ovariectomy and strain.

作者信息

Becker H C, Anton R F, De Trana C, Randall C L

出版信息

Life Sci. 1985 Oct 7;37(14):1293-300. doi: 10.1016/0024-3205(85)90244-9.

Abstract

Two experiments were conducted to investigate the influence of ovariectomy (OVX) on alcohol sensitivity in mice. In the first experiment, OVX, sham-operated, and nonsurgical control C57BL mice were examined for brain alcohol levels associated with alcohol-induced motor incoordination, alcohol-induced loss of righting reflex, and voluntary alcohol consumption. The second experiment employed four strains of mice (C57BL, C3H, DBA, and Swiss Webster) to evaluate the influence of OVX on alcohol-induced spontaneous activity. Taken together, the results indicated that surgical removal of the ovaries in mice does not influence alcohol-induced motor incoordination, loss of righting reflex, or spontaneous activity. Voluntary alcohol consumption, however, was affected by ovariectomy, since mice in the OVX group consumed less alcohol relative to body weight (g/kg) than controls.

摘要

进行了两项实验来研究卵巢切除术（OVX）对小鼠酒精敏感性的影响。在第一个实验中，对接受卵巢切除术、假手术和未手术的对照C57BL小鼠进行了检查，以确定与酒精诱导的运动不协调、酒精诱导的翻正反射丧失以及自愿酒精摄入量相关的脑酒精水平。第二个实验使用了四种品系的小鼠（C57BL、C3H、DBA和瑞士韦伯斯特）来评估卵巢切除术对酒精诱导的自发活动的影响。综合来看，结果表明，手术切除小鼠卵巢不会影响酒精诱导的运动不协调、翻正反射丧失或自发活动。然而，自愿酒精摄入量受到卵巢切除术的影响，因为卵巢切除组的小鼠相对于体重（克/千克）的酒精摄入量比对照组少。