Lin Yixiang, Xu Haoling, Zheng Jiayi, Lin Tianxin, Wang Minhui, Huang Tingting, Lin Fabin, Ye Qinyong, Cai Guoen
Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, China.
Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, China.
NPJ Parkinsons Dis. 2025 Jun 4;11(1):150. doi: 10.1038/s41531-025-01000-4.
The influence of functional gastrointestinal disorders (FGIDs) on the onset of Parkinson's disease (PD) remains unclear. Therefore, in this study, we examined the effect of FGIDs and their subtypes on the PD onset. In Cox proportional hazards model, FGIDs significantly increased the risk of PD incidence [hazard ratio (HR) = 1.74, 95% confidence interval (CI) = 1.30-2.33]. Similar results were also observed for functional dyspepsia (HR = 1.71, 95% CI = 1.17-2.52) and other functional intestinal disorders (other FIDs) (HR = 1.67, 95% CI = 1.00-2.78). Mediation analyses revealed that mental health scores mediated 10.00% and 8.32% of the association between FGIDs and functional dyspepsia and PD development. This cohort study discovered that FGIDs increase the risk of developing PD. Similar effects can also be observed in functional dyspepsia and other FIDs and mental health mediates part of the effect of FGIDs and functional dyspepsia on PD.
功能性胃肠疾病（FGIDs）对帕金森病（PD）发病的影响尚不清楚。因此，在本研究中，我们研究了FGIDs及其亚型对PD发病的影响。在Cox比例风险模型中，FGIDs显著增加了PD发病风险[风险比（HR）=1.74，95%置信区间（CI）=1.30-2.33]。功能性消化不良（HR=1.71，95%CI=1.17-2.52）和其他功能性肠道疾病（其他FIDs）（HR=1.67，95%CI=1.00-2.78）也观察到类似结果。中介分析显示，心理健康评分介导了FGIDs与功能性消化不良以及PD发展之间关联的10.00%和8.32%。这项队列研究发现，FGIDs会增加患PD的风险。在功能性消化不良和其他FIDs中也可观察到类似影响，且心理健康介导了FGIDs和功能性消化不良对PD影响的一部分。
