实时远程运动对癌症幸存者生活质量及其他健康相关结局的影响：一项随机对照试验

Effects of live-remote exercise on quality of life and other health-related outcomes in cancer survivors: a randomised controlled trial.

作者信息

Kotte Melissa, Bolam Kate A, Altena Renske, Cormie Prue, Wengström Yvonne, Mijwel Sara

机构信息

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Cardiometabolic Health and Exercise Physiology Lab, Baker Heart and Diabetes Institute, Melbourne, Australia.

出版信息

J Cancer Surviv. 2025 Jun 5. doi: 10.1007/s11764-025-01845-x.

DOI:10.1007/s11764-025-01845-x

PMID:40467967

Abstract

PURPOSE

Exercise following cancer treatment has been shown to improve health-related quality of life (HRQoL) and other important health outcomes, yet barriers to participation prevent many cancer survivors from exercising according to recommendations. Live-remote exercise methods could improve accessibility; however, evidence on their efficacy is limited. The EX-MED Cancer Sweden randomised controlled trial compared the effects of a 12-week live-remote online exercise intervention to usual care in adult cancer survivors.

METHODS

Two hundred adults who had completed curative treatment for breast, prostate, or colorectal cancer were randomised to a 12-week live-remote online exercise intervention or a usual care control group. Intervention effects on the primary outcome overall HRQoL (EORTC-QLQ-C30) and secondary outcomes cardiorespiratory fitness (CRF), muscle strength, physical function, body composition, and other patient-reported outcomes were determined by comparing changes from baseline to 3 (primary timepoint) and 6 months between groups.

RESULTS

No significant effect was observed on overall HRQoL. However, live-remote exercise resulted in significant improvements at 3 months on the physical functioning domain of HRQoL (p ≤ 0.001), five-times sit-to-stand (p = 0.003), and moderate-vigorous physical activity levels (p ≤ 0.001) as well as estimated VO (p = 0.045), and upper body strength (p = 0.010) at 3 and 6 months. No significant differences were observed between the groups on lower body strength, handgrip strength, fatigue, or the other functional domains or symptoms of the EORTC-QLQ-C30.

CONCLUSIONS

A 12-week live-remote exercise intervention did not lead to improvements in overall HRQoL; however, it did result in significant benefits in physical function, CRF, and upper body strength in adults treated for breast, prostate, or colorectal cancer. These findings add to the limited evidence on the effects of virtually supervised exercise for cancer survivors.

IMPLICATIONS FOR CANCER SURVIVORS

EX-MED Cancer Sweden addresses common exercise barriers for cancer survivors while providing the benefits of supervised exercise.

TRIAL REGISTRATION

NCT05064670, Trial registered on October 1, 2021, https://clinicaltrials.gov/ct2/show/NCT05064670.

摘要

目的

癌症治疗后的运动已被证明可改善健康相关生活质量（HRQoL）及其他重要健康结局，但参与运动的障碍使许多癌症幸存者无法按建议进行锻炼。远程实时运动方法可能会提高可及性；然而，关于其效果的证据有限。瑞典EX-MED癌症随机对照试验比较了为期12周的远程实时在线运动干预与成人癌症幸存者常规护理的效果。

方法

200名完成乳腺癌、前列腺癌或结直肠癌根治性治疗的成年人被随机分为为期12周的远程实时在线运动干预组或常规护理对照组。通过比较两组从基线到3个月（主要时间点）和6个月的变化，确定干预对主要结局总体HRQoL（EORTC-QLQ-C30）以及次要结局心肺适能（CRF）、肌肉力量、身体功能、身体成分和其他患者报告结局的影响。

结果

未观察到对总体HRQoL有显著影响。然而，远程实时运动在3个月时使HRQoL的身体功能领域（p≤0.001）、五次坐立试验（p = 0.003）、中等至剧烈身体活动水平（p≤0.001）以及3个月和6个月时的估计VO（p = 0.045）和上肢力量（p = 0.010）有显著改善。两组在下肢力量、握力、疲劳或EORTC-QLQ-C30的其他功能领域或症状方面未观察到显著差异。