Dizman Batuhan, Ruhi Mustafa Kemal
Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Turkey.
Lasers Med Sci. 2025 Jun 5;40(1):254. doi: 10.1007/s10103-025-04510-y.
Photothermal treatments require precise temperature control to achieve therapeutic effects without harming surrounding tissues. However, existing systems rely on expensive components for accuracy. This study explores whether a temperature-controlled laser system can be developed using cost-effective components while maintaining precision. The system was designed and built from scratch and then tested on samples with different optical properties to identify and address its limitations. The final design ensures accuracy without requiring a computer for monitoring and control, making the technology more accessible. Our research group developed the hardware and software for a temperature-controlled laser system. The operating algorithm was then optimized using phantom and ex vivo tissue. The IR array sensor was used with its factory calibration, and its accuracy was compared to that of another commercial IR temperature measurement device. Finally, the results of the temperature-controlled ex vivo application were compared to those obtained using corresponding constant laser power values. The developed system could distinguish between agar and lamb liver and adjust the irradiation parameters accordingly. In the experiments where the samples were kept at 42.5 °C, the mean and standard deviation of the agar gel and lamb liver tissue temperatures were 42.10 ±0.37 °C and 42.92 ±0.39 °C, respectively. Subsequent experiments demonstrated that the developed system maintained the lamb liver tissue temperature at set values, with a standard deviation of less than ± 0.48 °C. In this study, a precise, customizable, and relatively inexpensive temperature-controlled laser system was developed and tested. The operation algorithm was developed based on preliminary studies, and the precision was maintained on samples with distinct optical properties. Future studies should focus on making the device more compact and testing the system in in vivo models. Clinical trial number Not applicable.
光热治疗需要精确的温度控制以实现治疗效果而不损伤周围组织。然而，现有系统依靠昂贵的组件来保证精度。本研究探索是否可以使用具有成本效益的组件开发一个温度可控的激光系统，同时保持精度。该系统从零开始设计和构建，然后在具有不同光学特性的样品上进行测试，以识别和解决其局限性。最终设计确保了精度，无需计算机进行监测和控制，使该技术更易于使用。我们的研究小组开发了温度可控激光系统的硬件和软件。然后使用体模和离体组织对操作算法进行了优化。红外阵列传感器按其出厂校准使用，并将其精度与另一种商用红外温度测量设备的精度进行了比较。最后，将温度可控离体应用的结果与使用相应恒定激光功率值获得的结果进行了比较。所开发的系统能够区分琼脂和羊肝，并相应地调整照射参数。在将样品保持在42.5°C的实验中，琼脂凝胶和羊肝组织温度的平均值和标准差分别为42.10±0.37°C和42.92±0.39°C。随后的实验表明，所开发的系统将羊肝组织温度维持在设定值，标准差小于±0.48°C。在本研究中，开发并测试了一种精确、可定制且相对便宜的温度可控激光系统。操作算法是基于初步研究开发的，并且在具有不同光学特性的样品上保持了精度。未来的研究应侧重于使设备更紧凑，并在体内模型中测试该系统。临床试验编号不适用。
