居家低强度运动游戏对轻度认知障碍个体认知功能的影响：一项随机对照试验的研究方案
Effects of home-based, low-intensity exergaming on cognitive function of individuals with mild cognitive impairment: a study protocol for a randomized controlled trial.
作者信息
Kumfu Sirintip, Sungkarat Somporn, Boripantakul Sirinun, Sa-Nguanmoo Piangkwan, Chattipakorn Siriporn C
机构信息
Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
出版信息
BMC Geriatr. 2025 Jun 4;25(1):408. doi: 10.1186/s12877-025-06054-w.
BACKGROUND
Although older adults with Mild Cognitive Impairment (MCI) face an increased risk of dementia, accumulating evidence has revealed that their cognitive functions could revert to normal levels with effective interventions. Exercise, particularly a combination of physical and cognitive training delivered in the form of an exergame, has shown promising effects in improving cognitive function of older adults with MCI. Nonetheless, previous research often prescribed center-based, moderate to vigorous intensity exercise, posing potential risks to older adults with physical or medical conditions as well as limiting accessibility for those with schedule or transportation constraints. Therefore, this study aims to evaluate the effects of home-based, low-intensity, combined physical-cognitive exercise in the form of an exergame, on cognitive function in individuals with MCI and to further investigate potential biomarkers linking the effectiveness of the exercise program to cognitive alterations.
METHODS
Sixty-four older adults with MCI will be enrolled and randomly allocated to either the exercise group or the control group. The exercise group will engage in a low-intensity, combined physical-cognitive exercise through an exergame, with a 50-minute session, 3 times per week for 12 consecutive weeks. The control group will not receive any intervention. Primary outcome measures will be cognitive performance (global cognition, executive function, memory, and attention), and secondary outcome measures will be plasma biomarkers and physical performance. All assessments will be administered at baseline and after a 12-week intervention.
DISCUSSION
The findings of this study might provide valuable insights into an effective and practical intervention program aimed at improving cognitive function of older adults with MCI. The low-intensity, home-based exergaming could have considerable clinical implications, as it has the potential to enhance accessibility for individuals who are unable to engage in high-intensity exercise or attend center-based exercise programs.
TRIAL REGISTRATION
ClinicalTrials.gov identifier: NCT06201533, Registered January 11, 2024.
背景
尽管患有轻度认知障碍（MCI）的老年人患痴呆症的风险增加，但越来越多的证据表明，通过有效的干预措施，他们的认知功能可以恢复到正常水平。运动，特别是以运动游戏形式进行的身体和认知训练相结合的方式，已显示出对改善患有MCI的老年人的认知功能具有显著效果。然而，以往的研究通常规定在中心进行中度至剧烈强度的运动，这对患有身体或医疗状况的老年人存在潜在风险，同时也限制了那些有日程安排或交通限制的人的可及性。因此，本研究旨在评估以运动游戏形式进行的家庭式、低强度、身体 - 认知结合运动对MCI个体认知功能的影响，并进一步研究将运动计划的有效性与认知改变联系起来的潜在生物标志物。
方法
将招募64名患有MCI的老年人，并随机分配到运动组或对照组。运动组将通过运动游戏进行低强度的身体 - 认知结合运动，每次训练50分钟，每周3次，连续进行12周。对照组不接受任何干预。主要结局指标将是认知表现（整体认知、执行功能、记忆和注意力），次要结局指标将是血浆生物标志物和身体表现。所有评估将在基线和12周干预后进行。
讨论
本研究的结果可能为旨在改善患有MCI的老年人认知功能的有效且实用的干预计划提供有价值的见解。低强度、家庭式的运动游戏可能具有重要的临床意义，因为它有可能提高那些无法进行高强度运动或参加中心运动项目的人的可及性。
试验注册
ClinicalTrials.gov标识符：NCT06201533，于2024年1月11日注册。
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