Moslehabadi Radmehr Rahimi, Hedayati Zeinab, Mazraeh Mohammad, Asghar Shakiba, Rouhani Farzaneh, Morsali Ali
Department of Inorganic Chemistry, Shahid Beheshti University, P.O. Box 19839-69411, Tehran, Iran.
Department of Chemistry, Faculty of Basic Sciences, Tarbiat Modares University, P.O. Box 14117-13116, Tehran, Iran.
J Mater Chem B. 2025 Jul 2;13(26):7554-7608. doi: 10.1039/d5tb00764j.
Metal-organic frameworks (MOFs) have traditionally been valued for their stability, which is crucial for applications in catalysis, separation, and storage. However, instability, often considered a drawback, can serve as a functional advantage in specific applications. This study explores the benefits of unstable MOFs, particularly in areas where controlled degradation is desirable. Instability is an inherent characteristic of many MOFs, and rather than being viewed as a limitation, it can be harnessed to achieve remarkable outcomes. Sacrificial MOFs, which undergo complete or partial decomposition, present unique opportunities in biomedical applications, including drug delivery, bio-imaging, and wound healing, where structural breakdown can be advantageous. Furthermore, instability can be strategically utilized to create temporary scaffolds, controlled-release systems, and transient functional materials. By shifting the perspective from stability as a prerequisite to instability as an asset, this review highlights and underscores the high potential of labile MOFs and their emerging role in diverse fields beyond conventional applications. Therefore, it's critical to learn about potential future uses for sacrificial MOFs, and it's particularly opportune to offer a review in this field. Herein, we provide a description of all applications and characterization in sacrificial MOFs with recent examples and a full discussion about sacrificial MOFs.
金属有机框架材料（MOFs）传统上因其稳定性而受到重视，这种稳定性对于催化、分离和储存等应用至关重要。然而，通常被视为缺点的不稳定性，在特定应用中却可成为一种功能优势。本研究探讨了不稳定MOFs的益处，特别是在需要可控降解的领域。不稳定性是许多MOFs的固有特性，不应将其视为一种限制，而是可以加以利用以实现显著成果。会发生完全或部分分解的牺牲性MOFs在生物医学应用中呈现出独特机遇，包括药物递送、生物成像和伤口愈合，在这些应用中结构分解可能具有优势。此外，不稳定性可被策略性地用于创建临时支架、控释系统和瞬态功能材料。通过将视角从把稳定性作为前提条件转变为将不稳定性视为一种资产，本综述突出并强调了不稳定MOFs的高潜力及其在传统应用之外的不同领域中正在兴起的作用。因此，了解牺牲性MOFs未来的潜在用途至关重要，并在此领域进行综述尤为适时。在此，我们通过近期实例对牺牲性MOFs的所有应用和表征进行了描述，并对牺牲性MOFs进行了全面讨论。
