Hotta H, Sanchez L F, Takada H, Homma M, Kotani S
Microbiol Immunol. 1985;29(6):533-41. doi: 10.1111/j.1348-0421.1985.tb00855.x.
Dengue virus multiplication in cultures of a murine myelomonocytic cell line (WEHI-3) as well as mouse peritoneal macrophages was enhanced by treatment of the cells with lipophilic derivatives of muramyl peptides for 2 or 3 days before virus inoculation, but not for 2 hr before virus inoculation or during the adsorption period. The infection-enhancing activity of the materials was dependent on their chemical structure, correlating with their immunoadjuvanticity. The infection enhancement in WEHI-3 cells was due primarily to an increase in the number of virus-infected cells which was accompanied by an increased cellular capacity to bind latex particles to their cell surfaces.
在病毒接种前2或3天，用胞壁酰肽的亲脂性衍生物处理鼠骨髓单核细胞系（WEHI-3）培养物以及小鼠腹腔巨噬细胞，可增强登革病毒在其中的增殖，但在病毒接种前2小时或吸附期进行处理则无此效果。这些物质的感染增强活性取决于其化学结构，与它们的免疫佐剂活性相关。WEHI-3细胞中的感染增强主要是由于病毒感染细胞数量增加，同时细胞将乳胶颗粒结合到其细胞表面的能力也增强。
