Santorelli Gillian, Lewer Dan, Nirantharakumar Krishnarajah, Lee Siang Ing, Phillips Katherine, McEachan Rosemary R C, Wright John
Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, England, BD9 6RJ, UK.
Institute for Applied Health Research, University of Birmingham, Birmingham, England, UK.
Wellcome Open Res. 2025 May 16;9:210. doi: 10.12688/wellcomeopenres.20992.2. eCollection 2024.
Born in Bradford (BiB) is a family cohort study with linked routine health records. We calculated the rates of common health conditions and explored differences between White European and South Asian participants.
21 health conditions were identified using diagnostic codes and prescription records extracted from electronic health records. We calculated 2-year period prevalence before recruitment and incidence rates per 1000 person-years were calculated from recruitment to the end of 2021 (or censoring). Age-adjusted Cox proportional hazard models estimated hazard ratios (HR) by ethnicity.
The sample included 9,784 mothers, 52% were of South Asian heritage and 48% were White European. The highest prevalence and incidence rates were observed for common mental health disorders and eczema. South Asian women had higher incidence of 14 conditions, including diabetes (HR 3.94 [95% CI 3.15, 4.94]), chronic liver disease (2.98 [2.29, 3.88]) and thyroid disorders (1.87 [1.50, 2.33]), but lower incidence of cancer (0.51 [0.38, 0.68]), other and common mental health disorders (0.56 [0.45, 0.71] and 0.69 [0.64, 0.74] respectively), and other neuromuscular conditions (0.63 [0.49, 0.82]).
CONCLUSIONS/DISCUSSION: This study reveals significant differences in the occurrence of several non-communicable health conditions between White European and South Asian women. The observed higher incidence of several conditions in South Asian women, consistent with established knowledge regarding elevated risks for diseases such as diabetes, likely reflects the complex interplay of social, cultural, lifestyle, environmental, and genetic determinants. These findings emphasise the need for culturally sensitive and targeted public health interventions aimed at addressing modifiable risk factors at both the individual and systemic levels to alleviate the burden of long-term health conditions and reduce existing health inequalities.
“布拉德福德出生队列研究”（BiB）是一项关联了常规健康记录的家庭队列研究。我们计算了常见健康状况的发生率，并探讨了欧洲白人参与者与南亚参与者之间的差异。
利用从电子健康记录中提取的诊断编码和处方记录确定了21种健康状况。我们计算了招募前的两年患病率，并计算了从招募到2021年底（或截尾）每1000人年的发病率。年龄调整后的Cox比例风险模型按种族估计风险比（HR）。
样本包括9784名母亲，其中52%为南亚裔，48%为欧洲白人。常见心理健康障碍和湿疹的患病率和发病率最高。南亚女性有14种疾病的发病率较高，包括糖尿病（HR 3.94 [95% CI 3.15, 4.94]）、慢性肝病（2.98 [2.29, 3.88]）和甲状腺疾病（1.87 [1.50, 2.33]），但癌症发病率较低（0.51 [0.38, 0.68]），其他和常见心理健康障碍发病率较低（分别为0.56 [0.45, 0.71]和0.69 [0.64, 0.74]），其他神经肌肉疾病发病率较低（0.63 [0.49, 0.82]）。
结论/讨论：本研究揭示了欧洲白人女性与南亚女性在几种非传染性健康状况的发生方面存在显著差异。南亚女性中几种疾病的较高发病率，与糖尿病等疾病风险升高的既定知识一致，可能反映了社会、文化、生活方式、环境和遗传决定因素的复杂相互作用。这些发现强调了需要有文化敏感性和针对性的公共卫生干预措施，旨在在个体和系统层面解决可改变的风险因素，以减轻长期健康状况的负担并减少现有的健康不平等。
