Department of Plastic Surgery of Peking Union Medical College Hospital Of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Aesthetic Plast Surg. 2021 Feb;45(1):263-272. doi: 10.1007/s00266-020-01684-4. Epub 2020 Mar 23.
Botulinum toxin injection, micro-needling injection, and filler injection are the most widely used non-surgical facial cosmetic treatments. Hypersensitivity reactions associated with injections have not received sufficient attention due to their low incidence rates. The authors tried to summarize the characteristics of the hypersensitivity caused by cosmetic injections and helped to improve the diagnosis and treatment.
A comprehensive search of the PubMed database to September 2019 was performed. Articles were screened using predetermined inclusion and exclusion criteria. Data collected included patient characteristics, injection information (injected material, trade name, location of injection, symptoms of allergy, time of onset), diagnostic examination, treatment, and prognosis.
A total of 14 articles (57 patients) were included. There were 3 patients receiving botulinum toxin injection, 3 patients receiving micro-needling injection, and 46 patients receiving hyaluronic acid injection. Five patients were injected with collagen, polyacrylamide, paraffin, alkyl-imide or hyaluronidase, separately. The symptoms were redness, swelling, itching or induration at the injection site. The diagnosis and treatment methods vary greatly depending on the injection fillers. Removing the injected filler is the primary treatment.
Although hypersensitivity reaction is a relatively uncommon adverse event, more practice guidelines and research on diagnosis and treatment are demanded to help improve the outcomes.
This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the table of contents or the online instructions to authors www.springer.com/00266 .
肉毒毒素注射、微针注射和填充剂注射是最广泛使用的非手术面部美容治疗方法。由于其发生率低，与注射相关的过敏反应尚未得到足够重视。作者试图总结美容注射引起的过敏反应的特征，并有助于提高诊断和治疗水平。
对 2019 年 9 月之前的 PubMed 数据库进行全面检索。使用预定的纳入和排除标准筛选文章。收集的数据包括患者特征、注射信息（注射材料、商品名、注射部位、过敏症状、发病时间）、诊断检查、治疗和预后。
共纳入 14 篇文章（57 例患者）。其中 3 例接受肉毒毒素注射，3 例接受微针注射，46 例接受透明质酸注射。5 例患者分别注射胶原蛋白、聚丙烯酰胺、石蜡、烷基酰胺或透明质酸。症状为注射部位发红、肿胀、瘙痒或硬结。诊断和治疗方法因注射填充物而异。去除注射填充物是主要治疗方法。
尽管过敏反应是一种相对少见的不良反应，但需要更多的诊断和治疗实践指南和研究，以帮助改善治疗效果。
证据等级 III：本杂志要求作者为每篇文章分配一个证据等级。有关这些循证医学评级的完整描述，请参阅目录或作者在线说明 www.springer.com/00266 。
