Yan Wei, Ji Lei, Zha Yunfeng, Dong Fenfen, Xu Deshun
Huzhou Center for Disease Control and Prevention, Huzhou, 313000, People's Republic of China.
Infect Drug Resist. 2025 May 31;18:2765-2777. doi: 10.2147/IDR.S521802. eCollection 2025.
serovar Typhimurium (. Typhimurium) and its monophasic variant, 4,[5],12:i:-, have become two of the most frequently isolated serovars worldwide, in both humans and animals. This study investigated the antimicrobial resistance and genomic characteristics of these two serovar .
Between 2021 and 2023, a total of 90 . Typhimurium and 4,[5],12:i:-were collected from clinical and food samples in Huzhou. Their antimicrobial resistance phenotype and genes, virulence genes, and phylogenetic relationship were analyzed.
4,[5],12:i:-, which all belong to ST34, has become the main serotype of isolated in Huzhou instead of . Typhimurium. Notably, we observed a higher incidence of infections among the young population (<5 years old). The 90 isolates were mainly resistant to tetracycline (94.4%), ampicillin (72.2%), and trimethoprim/sulfamethoxazole (70.0%), with multidrug resistance (MDR) rates as high as 93.3%. Genome sequencing indicated that these isolates possessed 39 antimicrobial resistance genes and 184 virulence genes.
This research enhances our understanding of . Typhimurium and 4,[5],12:i:- infections, which is helpful to guide clinical responses.
鼠伤寒沙门氏菌（. Typhimurium）及其单相变体4,[5],12:i:-已成为全球人类和动物中最常分离出的两种血清型。本研究调查了这两种血清型的抗菌药物耐药性和基因组特征。
2021年至2023年期间，共从湖州的临床和食品样本中收集了90株鼠伤寒沙门氏菌和4,[5],12:i:-。分析了它们的抗菌药物耐药表型和基因、毒力基因以及系统发育关系。
全部属于ST34的4,[5],12:i:-已成为湖州分离出的主要血清型，而非鼠伤寒沙门氏菌。值得注意的是,我们观察到年轻人群（<5岁）中感染发生率较高。这90株分离株主要对四环素（94.4%）、氨苄西林（72.2%）和甲氧苄啶/磺胺甲恶唑（70.0%）耐药，多重耐药（MDR）率高达93.3%。基因组测序表明，这些分离株拥有39个抗菌药物耐药基因和184个毒力基因。
本研究增进了我们对鼠伤寒沙门氏菌和4,[5],12:i:-感染的了解，有助于指导临床应对。
