Xu Deshun, Ji Lei, Yan Wei, Chen Liping
Huzhou Center for Disease Control and Prevention, 999 Changxing Road, Huzhou, Zhejiang 313000, China.
Can J Infect Dis Med Microbiol. 2022 Jun 21;2022:7280376. doi: 10.1155/2022/7280376. eCollection 2022.
subspecies causes salmonellosis in humans and animals and is an important antecedent of food infections worldwide. This study collected 105 clinical . isolates from diarrhoea samples from six sentinel hospitals for active surveillance of foodborne diseases in Huzhou, China, between 2018 and 2020. These represented all the isolates collected in Huzhou during that period.
The isolates were characterized by serovar determination, antimicrobial susceptibility tests, and pulse-field gel electrophoresis (PFGE) typing.
The 105 strains were mainly . (35.24%, 95% CI from 25.95 to 44.53%) and . (18.10%, 95% CI from 10.61 to 25.58%). Testing indicated that the resistance rate of the strains ranged from 0.00% to 70.48%, and the highest resistance rate was for ampicillin (70.48%; 74/105), followed by tetracycline (67.62%; 71/105) and doxycycline (65.71%; 69/105). Following I digestion, the 105 strains yielded 93 PFGE patterns, and 15 clones had similarity values >85.00%.
Our analyses revealed the serovar distribution of isolates recovered from diarrhoea patients and the characteristics of resistant strains in Huzhou from 2018 to 2020. Our results highlight a serovar shift and a concerning number of multidrug-resistant (MDR) strains. Continued surveillance of and their MDR profiles and efforts to control the rapid increase in antimicrobial resistance among in Huzhou are needed.
该亚种可导致人类和动物感染沙门氏菌病，是全球食物感染的重要诱因。本研究收集了2018年至2020年间中国湖州6家哨点医院腹泻样本中的105株临床分离株，用于食源性疾病的主动监测。这些分离株代表了该时期湖州收集的所有分离株。
通过血清型测定、药敏试验和脉冲场凝胶电泳（PFGE）分型对分离株进行鉴定。
105株菌株主要为……（35.24%，95%置信区间为25.95%至44.53%）和……（18.10%，95%置信区间为10.61%至25.58%）。检测表明，这些菌株的耐药率在0.00%至70.48%之间，耐药率最高的是氨苄西林（70.48%；74/105），其次是四环素（67.62%；71/105）和强力霉素（65.71%；69/105）。经I酶切后，105株菌株产生了93种PFGE图谱，15个克隆的相似性值>85.00%。
我们的分析揭示了2018年至2020年湖州腹泻患者分离株的血清型分布及耐药菌株特征。我们的结果凸显了血清型转变以及数量可观的多重耐药（MDR）菌株。需要持续监测该亚种及其MDR谱，并努力控制湖州该亚种耐药性的快速增长。
