Leso Veruscka, Fontana Luca, Pacella Daniela, Barbato Giuseppe, Della Puca Vincenzo, Calabrese Edward J, Iavicoli Ivo
Department of Public Health, Section of Occupational Medicine, University of Naples "Federico II", Naples, Italy.
Department of Public Health, University of Naples "Federico II", Naples, Italy.
Dose Response. 2025 Jun 3;23(2):15593258251344986. doi: 10.1177/15593258251344986. eCollection 2025 Apr-Jun.
To investigate the impact of chronic and low-dose ionizing radiation (IR) exposure on the workers' hematopoietic system. Hematological parameters in IR exposed healthcare workers (n. 180) were compared to those determined in unexposed controls (n. 180). The relationship with the 5-year cumulative doses: <0.45; 0.45-1.28 and >1.28 mSv, was assessed. Red blood cells (RBCs), hemoglobin (HB) and hematocrit (HCT) showed significant differences compared to controls. A non-linear relationship was determined with respect to the cumulative doses. RBCs showed a significant decrease at the first <0.45 mSv IR-dose compared to controls (4.72 ± 0.31 vs 4.90 ± 0.38 × 10/L; = .013) with a rising trend, although not significant, at the two highest doses. Comparably, at the two lowest doses, HB (135.8 ± 11.3, < .001 and 137.4 ± 10.1 g/L, < .001) and HCT (41.8 ± 2.7, < .005 and 41.7 ± 2.7%, < .001) significantly decreased compared to controls (143.9 ± 10.6 g/L and 43.16 ± 2.95%, respectively), while not significantly increased at the >1.28 mSv highest one. IR exposure affected the hematopoietic system according to an hormetic phenomenon, intended as a biphasic dose-response with a low-dose stimulation and a high-dose inhibition, and, potentially, through a triphasic dose-response. These results deserve attention to define/implement suitable IR occupational risk assessment and management strategies.
为研究长期低剂量电离辐射（IR）暴露对工作人员造血系统的影响。将接受IR暴露的医护人员（n = 180）的血液学参数与未暴露对照组（n = 180）所测定的参数进行比较。评估了与5年累积剂量（<0.45；0.45 - 1.28和>1.28 mSv）的关系。与对照组相比，红细胞（RBC）、血红蛋白（HB）和血细胞比容（HCT）显示出显著差异。确定了与累积剂量的非线性关系。与对照组相比，RBC在首个<0.45 mSv的IR剂量下显著降低（4.72 ± 0.31对4.90 ± 0.38×10/L；P = 0.013），在两个较高剂量下呈上升趋势，尽管不显著。同样，在两个较低剂量下，HB（135.8 ± 11.3，P < 0.001和137.4 ± 10.1 g/L，P < 0.001）和HCT（41.8 ± 2.7，P < 0.005和41.7 ± 2.7%，P < 0.001）与对照组（分别为143.9 ± 10.6 g/L和43.16 ± 2.95%）相比显著降低，而在>1.28 mSv的最高剂量下未显著增加。IR暴露根据一种兴奋效应现象影响造血系统，该现象被定义为具有低剂量刺激和高剂量抑制的双相剂量反应，并且可能通过三相剂量反应。这些结果值得关注，以定义/实施合适的IR职业风险评估和管理策略。
