Tian Xue-Lei, Lu Xue, Lyu Yu-Min, Zhao Hua, Liu Qing-Jie, Tian Mei
China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, P.R. China.
Laboratory of Toxicology, Henan Institute of Occupational Medicine, Zheng Zhou, P.R. China.
Dose Response. 2022 Feb 24;20(1):15593258221081373. doi: 10.1177/15593258221081373. eCollection 2022 Jan-Mar.
Plenty of reports focus on the effects of low-dose radiation (LDR) on peripheral blood lymphocytes in radiation workers. However, studies on red blood cells (RBCs) in radiation workers are rarely reported. Many studies focused on investigate the hemogram of radiation staffs without detecting other components of RBCs. To explore the potential effect of LDR on RBCs, we detected the level of RBC count, hemoglobin, 2,3-disphosphoglycerate (2,3-DPG), and glutathione (GSH), and then analyzed the factors on these indices in 106 medical radiation workers. As a result, RBC count was affected by sex, age, type of work, length of service (only for females), and annual effective dose (only for males). Hemoglobin status was affected by sex, type of work, and annual effective dose (only for males). Sex, age, and type of work had no effects on the concentration of 2,3-DPG and GSH. Length of service affected 2,3-DPG concentration, and annual effective dose affected GSH level. In conclusion, chronic occupational LDR exposure may have an effect on RBC count, hemoglobin status, and the concentration of 2,3-DPG and GSH in radiation workers to some extent. However, it is still unknown how this kind of influence affects the health of radiation workers.
大量报告聚焦于低剂量辐射（LDR）对辐射工作人员外周血淋巴细胞的影响。然而，关于辐射工作人员红细胞（RBC）的研究报道很少。许多研究专注于调查辐射工作人员的血常规，而未检测红细胞的其他成分。为了探究低剂量辐射对红细胞的潜在影响，我们检测了106名医学辐射工作人员的红细胞计数、血红蛋白、2,3-二磷酸甘油酸（2,3-DPG）和谷胱甘肽（GSH）水平，然后分析了影响这些指标的因素。结果显示，红细胞计数受性别、年龄、工作类型、工作年限（仅针对女性）和年有效剂量（仅针对男性）影响。血红蛋白状态受性别、工作类型和年有效剂量（仅针对男性）影响。性别、年龄和工作类型对2,3-DPG和GSH浓度无影响。工作年限影响2,3-DPG浓度，年有效剂量影响GSH水平。总之，长期职业性低剂量辐射暴露可能在一定程度上影响辐射工作人员的红细胞计数、血红蛋白状态以及2,3-DPG和GSH浓度。然而，这种影响如何作用于辐射工作人员的健康仍不清楚。
