Guo Jia-Jia, Liu Ning, Ma Zheng, Gong Zi-Jun, Liang Yue-Lang, Cheng Qi, Zhong Xin-Guang, Yao Zhen-Jiang
Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
The Sixth People's Hospital of Dongguan, Dongguan, China.
Dose Response. 2022 Jun 5;20(2):15593258221105695. doi: 10.1177/15593258221105695. eCollection 2022 Apr-Jun.
While previous studies have focused on the health effects of occupational exposure of radiations on medical radiation workers, few have analyzed the dose-response relationship between low radiation doses and changes in blood parameters. Even fewer studies have been conducted on industrial worker populations. Using a prospective cohort study design, this study collected health examination reports and personal dose monitoring data from 705 industrial irradiation workers who underwent regular physical examinations at Dongguan Sixth People's Hospital. The dose-response effects of low-dose ionizing radiation on blood parameters were assessed using a generalized linear model and restricted cubic spline model. Red blood cell counts decreased then increased, before decreasing again with increasing ionizing radiation. This was in contrast to the curve of the total platelet count after irradiation. Additionally, a radiation dose of 2.904 mSv was the turning point for the nonlinear curve of hemoglobin count changes. In conclusion, long-term, low-dose ionizing radiation affects blood cell levels in industrial irradiation workers. There is a nonlinear dose-response relationship between red blood cell, platelet, and hemoglobin counts and the cumulative radiation dose. These findings should alert radiation workers to seek preventive medical treatment before the occurrence of any serious hematopoietic disease.
虽然先前的研究主要关注职业性辐射暴露对医学放射工作人员的健康影响，但很少有研究分析低辐射剂量与血液参数变化之间的剂量反应关系。对产业工人人群进行的研究更是少之又少。本研究采用前瞻性队列研究设计，收集了在东莞市第六人民医院接受定期体检的705名产业辐照工人的健康检查报告和个人剂量监测数据。使用广义线性模型和受限立方样条模型评估低剂量电离辐射对血液参数的剂量反应效应。红细胞计数先下降后上升，然后随着电离辐射剂量增加再次下降。这与照射后血小板总数的曲线相反。此外，2.904毫希沃特的辐射剂量是血红蛋白计数变化非线性曲线的转折点。总之，长期低剂量电离辐射会影响产业辐照工人的血细胞水平。红细胞、血小板和血红蛋白计数与累积辐射剂量之间存在非线性剂量反应关系。这些发现应提醒辐射工作人员在任何严重造血疾病发生之前寻求预防性医疗。
