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美容透明质酸真皮填充剂注射后的急性肺部并发症

Acute Pulmonary Complications Following Cosmetic Hyaluronic Acid Dermal Filler Injections.

作者信息

Tan Sin Nee, Huan Nai-Chien, Hairudin Khairee Aqil, Harun Norra, Sivandan Shobhana, Andylim Nizafaziasyida Fauzee, Ibrahim Aishah, Abdul Razak Megat Razeem, Abdul Azih Muhammad Naimmuddin

机构信息

Respiratory Unit, Medical Department Tengku Ampuan Afzan Hospital Kuantan Malaysia.

Department of Respiratory Medicine Queen Elizabeth Hospital Kota Kinabalu Malaysia.

出版信息

Respirol Case Rep. 2025 Jun 4;13(6):e70227. doi: 10.1002/rcr2.70227. eCollection 2025 Jun.


DOI:10.1002/rcr2.70227
PMID:40470135
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12135025/
Abstract

Hyaluronic acid (HA) injectable dermal filler is widely used in cosmetic procedures, but it rarely leads to pulmonary complications. We present four patients with acute pulmonary complications after HA filler injections: three with organising pneumonia and one with acute pneumonitis. All presented with dyspnoea and cough; three received bilateral breast injections, and one received both breast and buttock injections. All patients received supportive management, including oxygen therapy, corticosteroids, and empirical antibiotics, whereby three responded well, but one succumbed. Clinicians ought to be vigilant of potential life-threatening pulmonary complications related to HA filler injections, as most procedures are performed in unassuming healthcare settings where catastrophic complications are not anticipated.

摘要

透明质酸(HA)注射用真皮填充剂在美容手术中广泛使用,但很少引发肺部并发症。我们报告了4例HA填充剂注射后出现急性肺部并发症的患者:3例为机化性肺炎,1例为急性肺炎。所有患者均表现为呼吸困难和咳嗽;3例接受双侧乳房注射,1例接受乳房和臀部注射。所有患者均接受了支持性治疗,包括氧疗、皮质类固醇和经验性抗生素治疗,其中3例反应良好,但1例死亡。临床医生应警惕与HA填充剂注射相关的潜在危及生命的肺部并发症,因为大多数手术是在不认为会出现灾难性并发症的普通医疗环境中进行的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f7/12135025/feadfdd5919c/RCR2-13-e70227-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f7/12135025/d4a23aa166ae/RCR2-13-e70227-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f7/12135025/80e4eb2a57f2/RCR2-13-e70227-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f7/12135025/9f9a638af66c/RCR2-13-e70227-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f7/12135025/14ae624acf95/RCR2-13-e70227-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f7/12135025/feadfdd5919c/RCR2-13-e70227-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f7/12135025/d4a23aa166ae/RCR2-13-e70227-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f7/12135025/80e4eb2a57f2/RCR2-13-e70227-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f7/12135025/9f9a638af66c/RCR2-13-e70227-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f7/12135025/14ae624acf95/RCR2-13-e70227-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f7/12135025/feadfdd5919c/RCR2-13-e70227-g001.jpg

相似文献

[1]
Acute Pulmonary Complications Following Cosmetic Hyaluronic Acid Dermal Filler Injections.

Respirol Case Rep. 2025-6-4

[2]
The effect of combined hyaluronic acid filler injection and radiofrequency treatment: A clinic histological analysis.

J Cosmet Dermatol. 2023-3

[3]
Evaluation of Current Literature on Complications Secondary to Lip Augmentation Following Dermal Filler Injection.

J Clin Aesthet Dermatol. 2023-7

[4]
Management strategies for vascular complications in hyaluronic acid filler injections: A case series analysis.

J Cosmet Dermatol. 2023-12

[5]
A treatment algorithm for hyaluronic acid filler related complications of the face.

J Plast Reconstr Aesthet Surg. 2024-4

[6]
Management of Delayed Complications of Hyaluronic Acid Fillers: Case Series From the Middle East.

J Cosmet Dermatol. 2025-4

[7]
Causes and management of sight threatening complications of dermal filler injections: A review.

Clin Exp Ophthalmol. 2024-4

[8]
Biological properties of a new volumizing hyaluronic acid filler: a systematic review.

J Drugs Dermatol. 2015-1

[9]
The role of ultrasound in facial hyaluronic acid dermal filler injections - A review article.

Clin Imaging. 2025-3

[10]
The "ART" of facial filler injections: Avoid, recognize, and treat hyaluronic acid-induced complications.

J Cosmet Dermatol. 2020-9

本文引用的文献

[1]
Pulmonary adverse events of breast silicone implants and silicone injection.

Respir Med Res. 2023-11

[2]
Death from Pulmonary Embolism Caused by Vaginal Injection of Hyaluronic Acid: a Case Report and a Literature Review.

Aesthetic Plast Surg. 2023-8

[3]
Death Caused by Vaginal Injection of Hyaluronic Acid and Collagen: A Case Report.

Aesthet Surg J. 2020-4-14

[4]
Hyaluronic acid-induced diffuse alveolar hemorrhage: unknown complication induced by a well-known injectable agent.

Ann Transl Med. 2019-1

[5]
Idiopathic interstitial pneumonias: review of the latest American Thoracic Society/European Respiratory Society classification.

Radiol Bras. 2018

[6]
Global Aesthetics Consensus: Avoidance and Management of Complications from Hyaluronic Acid Fillers-Evidence- and Opinion-Based Review and Consensus Recommendations.

Plast Reconstr Surg. 2016-6

[7]
The Hyaluronic Acid Fillers: Current Understanding of the Tissue Device Interface.

Facial Plast Surg Clin North Am. 2015-11

[8]
A case of nonthrombotic pulmonary embolism after facial injection of hyaluronic Acid in an illegal cosmetic procedure.

Tuberc Respir Dis (Seoul). 2014-8

[9]
A case of diffuse alveolar hemorrhage associated with hyaluronic acid dermal fillers.

Am J Case Rep. 2014-5-9

[10]
Pulmonary emboli from therapeutic sodium hyaluronate.

Respir Care. 2012-3-12

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