Tan Sin Nee, Huan Nai-Chien, Hairudin Khairee Aqil, Harun Norra, Sivandan Shobhana, Andylim Nizafaziasyida Fauzee, Ibrahim Aishah, Abdul Razak Megat Razeem, Abdul Azih Muhammad Naimmuddin
Respiratory Unit, Medical Department Tengku Ampuan Afzan Hospital Kuantan Malaysia.
Department of Respiratory Medicine Queen Elizabeth Hospital Kota Kinabalu Malaysia.
Respirol Case Rep. 2025 Jun 4;13(6):e70227. doi: 10.1002/rcr2.70227. eCollection 2025 Jun.
Hyaluronic acid (HA) injectable dermal filler is widely used in cosmetic procedures, but it rarely leads to pulmonary complications. We present four patients with acute pulmonary complications after HA filler injections: three with organising pneumonia and one with acute pneumonitis. All presented with dyspnoea and cough; three received bilateral breast injections, and one received both breast and buttock injections. All patients received supportive management, including oxygen therapy, corticosteroids, and empirical antibiotics, whereby three responded well, but one succumbed. Clinicians ought to be vigilant of potential life-threatening pulmonary complications related to HA filler injections, as most procedures are performed in unassuming healthcare settings where catastrophic complications are not anticipated.
透明质酸(HA)注射用真皮填充剂在美容手术中广泛使用,但很少引发肺部并发症。我们报告了4例HA填充剂注射后出现急性肺部并发症的患者:3例为机化性肺炎,1例为急性肺炎。所有患者均表现为呼吸困难和咳嗽;3例接受双侧乳房注射,1例接受乳房和臀部注射。所有患者均接受了支持性治疗,包括氧疗、皮质类固醇和经验性抗生素治疗,其中3例反应良好,但1例死亡。临床医生应警惕与HA填充剂注射相关的潜在危及生命的肺部并发症,因为大多数手术是在不认为会出现灾难性并发症的普通医疗环境中进行的。
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