Parupati Varsha R, Vignesh Arun, Priyadarshini Anuradha, Sundaram Murugan, Swaminathan Dr Adikrishnan
Dermatology, Venereology, and Leprosy, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Cureus. 2025 May 5;17(5):e83510. doi: 10.7759/cureus.83510. eCollection 2025 May.
Chickenpox is a common viral infection that usually runs a benign course. Bullous varicella is an atypical presentation of chickenpox, which is usually seen in immunocompromised individuals. We describe a 54-year-old immunocompetent woman who presented to the emergency room with a 10-day history of fever and painful, fluid-filled lesions on her face, trunk, and extremities. Upon examination, the face, trunk, and extremities showed many vesicles, pustules, and bullae over an erythematous base. Multinucleated giant cells (MNGs) with acantholytic cells were visible in the Tzanck smear. A diagnosis of bullous varicella was made based on the appearance of the lesions and the results of the Tzanck smear. The patient was treated with intravenous acyclovir and antibiotics. We report this case due to the rarity of bullous varicella in immunocompetent adults.
水痘是一种常见的病毒感染，通常病程良性。大疱性水痘是水痘的一种非典型表现，常见于免疫功能低下的个体。我们描述了一名54岁免疫功能正常的女性，她因发热10天、面部、躯干和四肢出现疼痛性、充满液体的皮疹而就诊于急诊室。检查时，面部、躯干和四肢在红斑基础上可见许多水疱、脓疱和大疱。Tzanck涂片可见含棘层松解细胞的多核巨细胞（MNGs）。根据皮疹外观和Tzanck涂片结果诊断为大疱性水痘。患者接受了静脉注射阿昔洛韦和抗生素治疗。我们报告该病例是因为免疫功能正常的成年人中出现大疱性水痘较为罕见。
