Westblad Mimmi Eriksson, Nassef Sari Kokkonen, Blennow Mats, Jirwe Maria, Lindström Katarina
Department of Clinical Science, Intervention and Technology, Division of Paediatrics, Karolinska Institutet, Stockholm, Sweden.
Karolinska University Hospital, Medical Unit Health Allied Professionals, Stockholm, Sweden.
Acta Paediatr. 2025 Oct;114(10):2702-2709. doi: 10.1111/apa.70170. Epub 2025 Jun 5.
To explore the correlation between motor performance, health-related quality of life (HRQOL) and self-esteem in early adolescents treated with therapeutic hypothermia (TH) following neonatal hypoxic-ischaemic encephalopathy (HIE).
This cross-sectional study included 45 children (mean age 11 years) with a neonatal TH-treated HIE between 2007 and 2009 in Stockholm. Motor performance was assessed with Movement Assessment Battery for Children-2 (MABC-2), HRQOL by Paediatric Quality of Life Inventory (PedsQL 4.0) and self-esteem with 'I Think I Am -2'. Nonparametric statistical methods were applied.
Significant positive correlations were found between MABC-2 scores and all PedsQL 4.0 dimensions in parents' reports (p < 0.001-0.029). Parents reported lower PedsQL 4.0 Total scores for children below the 15th percentile on MABC-2 (p = 0.004), while the self-reports of the same children were not significant (p = 0.098). Motor performance did not affect children's self-esteem; no difference was found between the group above or the group below the 15th percentile (p = 0.881).
Differences between parent and child-reported outcomes suggest the need for continued follow-up of children treated with TH into adolescence, including HRQOL and self-esteem. Long-term assessment is necessary to identify challenges not captured in early childhood or by self-reports alone.
探讨新生儿缺氧缺血性脑病（HIE）后接受亚低温治疗（TH）的青少年早期运动表现、健康相关生活质量（HRQOL）和自尊之间的相关性。
这项横断面研究纳入了2007年至2009年在斯德哥尔摩接受新生儿TH治疗的45名HIE患儿（平均年龄11岁）。采用儿童运动评估量表第二版（MABC-2）评估运动表现，通过儿童生活质量量表（PedsQL 4.0）评估HRQOL，用“我认为我是-2”评估自尊。应用非参数统计方法。
在家长报告中，MABC-2评分与PedsQL 4.0的所有维度之间存在显著正相关（p<0.001-0.029）。家长报告MABC-2得分低于第15百分位的儿童PedsQL 4.0总分较低（p=0.004），而这些儿童的自我报告则无显著差异（p=0.098）。运动表现不影响儿童的自尊；第15百分位以上组和以下组之间未发现差异（p=0.881）。
家长和儿童报告结果之间的差异表明，需要对接受TH治疗的儿童持续随访至青春期，包括HRQOL和自尊。长期评估对于识别幼儿期未发现或仅靠自我报告未发现的挑战是必要的。
