Higginson J
Natl Cancer Inst Monogr. 1985 May;67:187-92.
The historical developments leading to the acceptance of the influence of dietary and behavioral aspects of our life-style on cancer are reviewed. However, present information is usually insufficient to permit description of the complex mechanisms involved that are unlikely to yield to classical epidemiologic approaches alone. Better integrated laboratory epidemiologic studies are required that use more advanced nonintervention techniques. Progress may be slow in the identification of such factors in view of the many parameters involved, the absence of a single predominant or avoidable cause in many cancers, and the lack of adequately developed laboratory techniques for epidemiologic application.
本文回顾了促使人们接受生活方式中的饮食和行为因素对癌症有影响这一观点的历史发展过程。然而，目前的信息通常不足以描述其中涉及的复杂机制，这些机制不太可能仅靠经典的流行病学方法就能得出结论。需要开展更好的综合实验室流行病学研究，采用更先进的非干预技术。鉴于涉及的参数众多、许多癌症不存在单一主要或可避免的病因以及缺乏充分发展的用于流行病学应用的实验室技术，识别此类因素的进展可能会很缓慢。
