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上肢关节压痛作为评估类风湿关节炎患者出勤主义的实用指标:一项横断面观察性研究。

Upper extremity joint tenderness as a practical indicator for assessing presenteeism in rheumatoid arthritis patients: A cross-sectional observational study.

作者信息

Naito Ryota, Taniguchi Masashi, Onizawa Hideo, Nakajima Tomoya, McCracken Kayo, Mori Masato, Hiwa Ryosuke, Nakamura Takuji, Onishi Akira, Matsuda Shuichi, Morinobu Akio, Hirose Shinji, Shinkawa Yutaka, Umehara Hisanori, Tanaka Masao

机构信息

Center for Rheumatic Diseases, Nagahama City Hospital, Shiga, Japan.

Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

出版信息

PLoS One. 2025 Jun 5;20(6):e0318047. doi: 10.1371/journal.pone.0318047. eCollection 2025.

Abstract

OBJECTIVE

Rheumatoid arthritis (RA) causes chronic polyarthritis and joint dysfunction, reducing work productivity. This reduction is mainly due to presenteeism, characterized by impaired work performance despite being present at work. This study aims to investigate the impact of specific joint involvement, particularly in the upper extremities, on work disability in RA patients.

METHODS

Annual surveys assessing work disability were conducted among RA outpatients enrolled in the Nagahama Riumachi Cohort at Nagahama City Hospital, using the Work Productivity and Activity Impairment Questionnaire (WPAI). A multivariate regression analysis was performed to examine the cross-sectional and longitudinal associations between self-reported presenteeism and the tender joint count (TJC) in the extremities across two WPAI surveys.

RESULTS

The analysis included 201 patients, 52% of whom reported presenteeism. Cross-sectional analysis revealed a significant positive correlation between three or more TJCs of the upper extremity and presenteeism, with a regression coefficient (β) = 17.9 (95% confidence interval [CI]: 9.85-25.9). Among the joints evaluated, the sum of TJCs in the shoulder area (β = 9.55, CI: 5.39-13.7) and the fingers (β = 1.60, CI: 0.35-2.85) were significantly correlated with presenteeism. Additionally, change in presenteeism was significantly correlated with change in upper extremity TJCs (β = 1.41, CI: 0.05-2.77). No significant correlation was observed between lower extremity TJCs and presenteeism in these multivariate regression analyses.

CONCLUSIONS

The upper extremity TJC is strongly associated with presenteeism in RA patients. Minimizing TJC in the upper extremities, particularly in the shoulders and fingers, could be important treatment goal to reduce work disability in RA patients.

摘要

目的

类风湿关节炎(RA)会导致慢性多关节炎和关节功能障碍,降低工作效率。这种效率降低主要归因于出勤主义,其特征是尽管出勤但工作表现受损。本研究旨在调查特定关节受累,尤其是上肢关节受累,对RA患者工作残疾的影响。

方法

在长浜市立医院参加长浜柳町队列研究的RA门诊患者中,使用工作效率和活动障碍问卷(WPAI)进行年度工作残疾评估调查。进行多变量回归分析,以检验两次WPAI调查中自我报告的出勤主义与四肢压痛关节计数(TJC)之间的横断面和纵向关联。

结果

分析纳入了201例患者,其中52%报告存在出勤主义。横断面分析显示,上肢三个或更多TJC与出勤主义之间存在显著正相关,回归系数(β)=17.9(95%置信区间[CI]:9.85-25.9)。在评估的关节中,肩部区域的TJC总和(β = 9.55,CI:5.39-13.7)和手指的TJC总和(β = 1.60,CI:0.35-2.85)与出勤主义显著相关。此外,出勤主义的变化与上肢TJC的变化显著相关(β = 1.41,CI:0.05-2.77)。在这些多变量回归分析中,未观察到下肢TJC与出勤主义之间存在显著相关性。

结论

上肢TJC与RA患者的出勤主义密切相关。尽量减少上肢,尤其是肩部和手指的TJC,可能是减少RA患者工作残疾的重要治疗目标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49cb/12140210/c27280871dc1/pone.0318047.g001.jpg

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