Rajeswaran Srinath, Rajan Durairaj Karthick
Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore- 641021. Tamil Nadu, India.
Department of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan- 410013, PR China.
Phytomedicine. 2025 Jul 25;143:156872. doi: 10.1016/j.phymed.2025.156872. Epub 2025 May 20.
Neophytadiene (NPT) [CH] or 7, 11, 15-Trimethyl-3-methylenehexadec-1-ene is a diterpene found in the important oil of various plants, including neem (Azadirachta indica). It possesses inhibitory properties against a range of enzymes. The prospective uses of neophytadiene in cosmetics, medicine, and agriculture have attracted much interest. Numerous pharmaceutical applications have been demonstrated, such as analgesic, anti-oxidant, anti-microbial, anti-cancer, anti-malarial, insecticidal, and neuroprotective properties. The extraction, purification, and biological uses of neophytadiene have received special attention. Drugs based on phytocompounds are being developed to create affordable treatments with minimal side effects and a wide range of therapeutic uses.
An overview of the function of neophytadiene is given in this article, along with information on its biological application, pharmacological significance, clinical uses, and its safety concerns.
A systematic literature review has been conducted using the PRISMA flow technique. Data for the literature survey was gathered online from various journals, computational databases, and search engines like Scopus, PubMed, Science Direct, and Google Scholar until March 2025.
The biological efficiency of neophytadiene was affirmed using several in vitro and animal model approaches. The efficacy, therapeutic utility and mechanism of neophytadiene against a range of disorders have all been attempted to be assessed. Neophytadiene plays an important role in the anti-inflammation pathway by TLR4 activation and neuroprotective role by PI3K/Akt signaling pathway. Notably, neophytadiene has shown efficacy against a wide range of organisms, including the malaria parasites. This molecule has multiple uses that can help reduce the severity of certain diseases. It also has the potential to be used as a pharmaceutical ingredient. To maximize its advantages, future research will examine the combined effects of neophytadiene with those of other medications and naturally occurring substances. The acceptance of these phytocompounds as potential medications is clarified by elaborating on their pharmacological safety dosages and various stages of clinical testing.
According to the reviewed studies, neophytadiene can be used as a medication candidate for treating diseases. However, these agents are used in therapeutic settings, so more clinical and experimental research is required in the future.
新植二烯（NPT）[CH]或7,11,15 - 三甲基 - 3 - 亚甲基十六 - 1 - 烯是一种二萜类化合物，存在于包括印楝（Azadirachta indica）在内的多种植物的重要油中。它对一系列酶具有抑制特性。新植二烯在化妆品、医药和农业中的潜在用途引起了广泛关注。已证明其具有多种药物应用，如镇痛、抗氧化、抗菌、抗癌、抗疟疾、杀虫和神经保护特性。新植二烯的提取、纯化及生物学用途受到了特别关注。基于植物化合物的药物正在被开发，以创造出副作用最小且具有广泛治疗用途的经济实惠的治疗方法。
本文概述了新植二烯的功能，以及其生物学应用、药理学意义、临床用途和安全性问题。
采用PRISMA流程技术进行了系统的文献综述。截至2025年3月，从Scopus、PubMed、Science Direct和谷歌学术等各种期刊、计算数据库和搜索引擎在线收集文献调查数据。
通过多种体外和动物模型方法证实了新植二烯的生物学功效。已尝试评估新植二烯对一系列疾病的疗效、治疗效用和作用机制。新植二烯通过激活TLR4在抗炎途径中发挥重要作用，并通过PI3K/Akt信号通路发挥神经保护作用。值得注意的是，新植二烯已显示出对包括疟原虫在内的多种生物体有效。这种分子有多种用途，可有助于减轻某些疾病的严重程度。它还具有作为药物成分的潜力。为了最大限度地发挥其优势，未来的研究将考察新植二烯与其他药物和天然物质的联合作用。通过阐述其药理学安全剂量和临床试验的各个阶段，阐明了这些植物化合物作为潜在药物的可接受性。
根据综述研究，新植二烯可作为治疗疾病的候选药物。然而，这些药物用于治疗环境中，因此未来需要更多的临床和实验研究。
