Tropé C, Danneskiold-Samsøe P, Hauksson A
Neoplasma. 1985;32(4):507-12.
In 92 patients receiving 270 cytostatic courses which all included cis-platinum, the antiemetic efficacy of medium- or high-dose metoclopramide was investigated. Metoclopramide was given intravenously 4 times during a 6-hour period (1/2 h before and 1 1/2, 3 1/2 and 5 1/2 h after cytostatic treatment) in a total dose of 1, 2, 4, 6, or 8 mg/kg. Nausea, emetic episodes, and side effects were registered during 24 h. The 1 mg/kg dose was given in 20 courses for which the average of emetic episodes was 16. In the four higher dosed groups the averages were 8, 8, 5, and 6, respectively. The average number of emetic episodes was significantly higher (p less than 0.001) in the 1 mg/kg metoclopramide group than in the 250 higher dosed courses. The frequency of side effects seemed independent of the dose in the interval 2-8 mg/kg while diarrhoea and other side effects tended to be less frequent in the 1 mg/kg metoclopramide group. Since antiemetic effect of metoclopramide in the dose interval 2-8 mg/kg did not increase with the dose, it is recommended to treat cis-platinum-induced emesis with 2 mg/kg metoclopramide given intravenously as 4 doses during a 6-hour period.
在92例接受了共270个含顺铂的细胞抑制剂疗程的患者中，研究了中、高剂量胃复安的止吐疗效。胃复安在6小时内静脉注射4次（细胞抑制剂治疗前半小时以及治疗后1个半小时、3个半小时和5个半小时），总剂量为1、2、4、6或8mg/kg。记录24小时内的恶心、呕吐发作及副作用情况。1mg/kg剂量组进行了20个疗程，呕吐发作的平均次数为16次。在四个较高剂量组中，平均次数分别为8次、8次、5次和6次。1mg/kg胃复安组的呕吐发作平均次数显著高于（p<0.001）其他250个较高剂量疗程组。在2 - 8mg/kg剂量范围内，副作用的发生频率似乎与剂量无关，而1mg/kg胃复安组的腹泻及其他副作用往往较少见。由于在2 - 8mg/kg剂量范围内胃复安的止吐效果并不随剂量增加，因此建议在6小时内分4次静脉注射2mg/kg胃复安来治疗顺铂引起的呕吐。
