木霉醇A-C，三种源自灵芝内生木霉属Trichoderma sp. GLQ02的新代谢产物及其抗炎活性。
Trichodermanols A-C, three new metabolites from the Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activity.
作者信息
Wu Ping-Ping, Qiu Xin-Huan, Yu Hua-Jin, Li Long-Jun, Cheng Xia, Chen Yi-Ping, Luo Qi
机构信息
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530200, China.
Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
出版信息
Fitoterapia. 2025 Jul;184:106657. doi: 10.1016/j.fitote.2025.106657. Epub 2025 Jun 3.
Trichodermanols A-C (1-3), an uncommon nor-steroid (1) and two novel 5/7 ring system sesquiterpenes (2 and 3), along with two known compounds identified as (1S,7R,10S,11R)-3-oxoguai-4-ene-11,12-diol (4) and cyclo-((S)-Pro-(R)-Leu) (5), were isolated and elucidated from a Ganoderma lucidum-derived endophytic fungus Trichoderma sp. GLQ02. Their chemical structures were elucidated on the basis of spectroscopic data and ECD and DP4 calculations. The biological activity of new isolates 1-3 was evaluated in LPS-stimulated RAW 264.7 cells. The results revealed that trichodermanol A (1) exhibited potential anti-inflammatory activity.
从灵芝来源的内生真菌木霉属Trichoderma sp. GLQ02中分离并鉴定出了木霉醇A - C（1 - 3），一种罕见的去甲甾体（1）和两种新型的5/7环系倍半萜（2和3），以及两种已知化合物，分别鉴定为(1S,7R,10S,11R)-3-氧代愈创木-4-烯-11,12-二醇（4）和环-((S)-脯氨酸-(R)-亮氨酸)（5）。基于光谱数据、电子圆二色谱（ECD）和DP4计算确定了它们的化学结构。在脂多糖（LPS）刺激的RAW 264.7细胞中评估了新分离物1 - 3的生物活性。结果表明，木霉醇A（1）具有潜在的抗炎活性。
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