来自内生真菌曲霉属TZS-Y4的类固醇、青霉醇和曲霉醇。
Steroids, peniciversiols and aspergilosidols from endophytic fungus Aspergillus sp. TZS-Y4.
作者信息
Li Yong-Fu, Zhang Rui-Han, Liu Ling-Yan, Yang Yi-Hui, Shen Yao, Li Qi-Ming, Li Min, Li Chang, Lu Xuan, Pei Yue-Hu
机构信息
International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, GuangZhou 510632, PR China; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, HarBin Medical University, HarBin 150081, PR China.
Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, HarBin Medical University, HarBin 150081, PR China.
出版信息
Fitoterapia. 2025 Jul;184:106650. doi: 10.1016/j.fitote.2025.106650. Epub 2025 May 28.
Endophytic fungi have emerged as a crucial resource for medicinal drug development. The genus Aspergillus, in particular, has yielded diverse bioactive secondary metabolites. In this study, we isolated nine steroids, five peniciversiols, and two aspergilosidols from the endophytic fungus Aspergillus sp. TZS-Y4. Among these, six steroids-camphoratins K-O (1-6) and one aspergilosidol, eupenoxide B (15), were identified as novel compounds. Their structures were elucidated through comprehensive NMR spectroscopy, HR-MS/MS analysis, experimental ECD, and calculated ECD data. Anti-inflammatory activity was assessed via an LPS-induced NO release assay in RAW264.7 cells, with compound 5 showing significant inhibitory effects.
内生真菌已成为药物开发的重要资源。特别是曲霉属已产生了多种具有生物活性的次生代谢产物。在本研究中，我们从内生真菌曲霉属菌株TZS-Y4中分离出9种甾体、5种青霉醇和2种曲霉醇。其中，6种甾体——樟芝菌素K - O（1 - 6）和1种曲霉醇，即优盘菌素B（15），被鉴定为新化合物。通过全面的核磁共振光谱、高分辨质谱/质谱分析、实验性电子圆二色谱和计算电子圆二色谱数据对其结构进行了阐明。通过脂多糖诱导的RAW264.7细胞中一氧化氮释放试验评估抗炎活性，化合物5显示出显著的抑制作用。
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