Zhao Qun, Si Yanran, Mao Lijuan, Wang Xing, Wang Peng, Li Shufan, Guo Zhaohui, Zhu Jianghua
Donghua University, Shanghai, 201620, China.
Shanghai International Studies University, Shanghai, 201620, China.
Sci Rep. 2025 Jun 5;15(1):19839. doi: 10.1038/s41598-025-04430-5.
To explore the relationship between resting EEG features and physical exercise among university students with depressive symptoms. A total of 1221 university students were recruited to complete a basic information form, the Patient Health Questionnaire-9 (PHQ-9), and the Physical Activity Rating Scale-3 (PARS-3). Resting EEG signals were collected from a subsample of 132 students. Latent Class Analysis was used to classify depressive symptoms, and the relationship between different resting EEG features and physical exercise was analyzed. Depressive symptoms among university students were classified into three latent classes, with Class 3 exhibiting the most severe symptoms. Significant differences were observed among the three groups in delta lateralization in the central region, alpha1 and alpha2 power in the parietal region, theta and alpha1 lateralization in the lateral frontal region, and alpha1 lateralization in the posterior temporal region (all p < 0.05). Alpha1 lateralization in the dorsolateral frontal cortex (F3, F4) was positively correlated with PARS-3 scores (r = 0.183, p = 0.036) and physical exercise intensity (r = 0.225, p = 0.010). Theta and alpha1 lateralization in the lateral frontal region (F7, F8) were positively correlated with exercise frequency (r = 0.229, p = 0.008; r = 0.214, p = 0.014, respectively). EEG lateralization features in the dorsolateral prefrontal and lateral frontal regions may serve as shared neurophysiological markers reflecting both depressive symptom severity and engagement in physical exercise among university students.
探讨有抑郁症状的大学生静息脑电图特征与体育锻炼之间的关系。共招募了1221名大学生来完成一份基本信息表、患者健康问卷-9（PHQ-9）和体育活动评分量表-3（PARS-3）。从132名学生的子样本中采集静息脑电信号。采用潜在类别分析对抑郁症状进行分类，并分析不同静息脑电图特征与体育锻炼之间的关系。大学生的抑郁症状被分为三个潜在类别，其中第3类症状最为严重。三组在中央区的δ波偏侧化、顶叶区的α1和α2功率、外侧额叶区的θ波和α1波偏侧化以及颞后区的α1波偏侧化方面存在显著差异（均p<0.05）。背外侧额叶皮层（F3、F4）的α1波偏侧化与PARS-3评分呈正相关（r = 0.183，p = 0.036），与体育锻炼强度呈正相关（r = 0.225，p = 0.010）。外侧额叶区（F7、F8）的θ波和α1波偏侧化与运动频率呈正相关（分别为r = 0.229，p = 0.008；r = 0.214，p = 0.014）。背外侧前额叶和外侧额叶区的脑电图偏侧化特征可能是反映大学生抑郁症状严重程度和体育锻炼参与度的共同神经生理标志物。
