Zuckerman M
Neuropsychobiology. 1985;13(3):121-8. doi: 10.1159/000118174.
Mania is a clinical state that could be described as sensation seeking behavior out of control. This article describes the biochemical correlates of the sensation seeking trait in normals including: gonadal hormones, monoamine oxidase, CSF norepinephrine, plasma dopamine-beta-hydroxylase and serotonin. The findings on monoamines and their neuroregulators in manic and depressed states of bipolar affective disorders are also discussed. Some hypotheses are suggested that link the personality disposition with the variations in the clinical state, and make some high sensation seekers 'at risk' for the affective disorder.
躁狂是一种可被描述为失控的寻求刺激行为的临床状态。本文描述了正常人中寻求刺激特质的生化关联，包括：性腺激素、单胺氧化酶、脑脊液去甲肾上腺素、血浆多巴胺-β-羟化酶和血清素。还讨论了双相情感障碍躁狂和抑郁状态下单胺及其神经调节剂的研究结果。提出了一些假设，将人格倾向与临床状态的变化联系起来，并使一些高寻求刺激者有患情感障碍的“风险”。
