Mikami Risako, Ishimaru Miho, Mizutani Koji, Shioyama Hidehiro, Matsuura Takanori, Aoyama Norio, Suda Tomonari, Kusunoki Yukako, Takeda Kohei, Anzai Tatsuhiko, Takahashi Kunihiko, Matsuo Koichiro, Aida Jun, Izumi Yuichi, Aoki Akira, Iwata Takanori
Department of Advanced Biomaterials, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Department of Dental Public Health, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
J Clin Periodontol. 2025 Sep;52(9):1254-1262. doi: 10.1111/jcpe.14190. Epub 2025 Jun 5.
The evidence for tooth splinting during periodontal regenerative therapy is limited. We aimed to investigate the adjunctive benefits of tooth splinting on clinical outcomes.
In total, 194 intrabony defects in 126 participants were prospectively evaluated over three years following periodontal regenerative therapy with an enamel matrix derivative. Clinical attachment level (CAL), probing depth (PD) and radiographic bone defect depth (RBD) were assessed. Propensity score matching (PSM) was employed to assign surgical sites to splinting and non-splinting groups, and multilevel regression was used to analyse the impact of tooth splinting on clinical outcomes.
Using PSM, 37 sites each from 32 and 30 participants in the splinting and non-splinting groups, respectively, were matched using the propensity score. Both groups included 26 and 11 sites with tooth mobility degrees 0 and 1, respectively. Significant improvements in CAL, PD and RBD were observed in both groups compared to baseline over the 3-year period. However, there were no significant differences among these parameters between the groups at the 1- and 3-year follow-ups.
No statistically significant adjunctive benefits of tooth splinting were observed in this study. However, further research with a larger sample size may be required to detect smaller but potentially clinically relevant effects.
牙周再生治疗期间牙齿夹板固定的证据有限。我们旨在研究牙齿夹板固定对临床结果的辅助益处。
总共126名参与者的194个骨内缺损在接受釉基质衍生物进行牙周再生治疗后的三年里进行了前瞻性评估。评估了临床附着水平(CAL)、探诊深度(PD)和放射学骨缺损深度(RBD)。采用倾向得分匹配(PSM)将手术部位分配到夹板固定组和非夹板固定组,并使用多水平回归分析牙齿夹板固定对临床结果的影响。
使用PSM,分别从夹板固定组的32名参与者和非夹板固定组的30名参与者中各选取37个部位,根据倾向得分进行匹配。两组分别包括26个和11个牙齿松动度为0和1的部位。在3年期间,两组与基线相比,CAL、PD和RBD均有显著改善。然而,在1年和3年随访时,两组之间这些参数没有显著差异。
本研究未观察到牙齿夹板固定具有统计学意义的辅助益处。然而,可能需要进行更大样本量的进一步研究,以检测较小但可能具有临床相关性的效果。