Arai H, Kobayashi K, Ichimiya Y, Kosaka K, Iizuka R
Neurosci Res. 1985 Aug;2(6):486-90. doi: 10.1016/0168-0102(85)90020-3.
Concentrations of free amino acids were measured in the cerebral cortices of post-mortem brains from 5 histologically verified cases of Alzheimer-type dementia (ATD) and 8 histologically normal controls. The concentration of glutamate in the ATD brains was significantly lower in the superior frontal, orbital, cingulate and inferior temporal cortices when compared with the control brains. The concentrations of taurine and gamma-aminobutyric acid in the ATD brains were significantly lower in the inferior temporal cortex. These findings suggest that amino acid neurons could be involved in ATD.
对5例经组织学证实的阿尔茨海默型痴呆（ATD）患者及8例组织学正常对照者的死后大脑皮质中的游离氨基酸浓度进行了测量。与对照大脑相比，ATD大脑中额叶上部、眶部、扣带回和颞下回皮质中的谷氨酸浓度显著降低。ATD大脑中颞下回皮质中的牛磺酸和γ-氨基丁酸浓度显著降低。这些发现表明氨基酸神经元可能与ATD有关。
