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双重麻烦：胰腺同步性小细胞癌和腺癌——病例报告

Double Trouble: Synchronous Small Cell Carcinoma and Adenocarcinoma of the Pancreas - Case Report.

作者信息

Thomas Raj Jessica, Zeineddine Mohammad, Chatterjee Arjun, Cruise Michael, Krishnamurthi Smitha, Chahal Prabhleen

机构信息

Department of Internal Medicine, Cleveland Clinic Akron General, Akron, OH, USA.

Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH, USA.

出版信息

Case Rep Oncol. 2025 May 14;18(1):653-658. doi: 10.1159/000545467. eCollection 2025 Jan-Dec.

DOI:10.1159/000545467
PMID:40475294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12140606/
Abstract

INTRODUCTION

Simultaneous presentation of primary tumors involving one isolated organ is few and far between. Pancreatic small cell carcinoma is unique, and it is rare to have both adenocarcinoma and small cell carcinoma present in unison within the pancreas.

CASE PRESENTATION

Presented is a 61-year-old male who was found to have synchronous small cell carcinoma and adenocarcinoma of the pancreas confirmed by endoscopic ultrasound-guided fine needle biopsy.

CONCLUSION

This case stands as a reminder that synchronous pancreatic cancer is a rarity and possibility of multiple primary malignant tumors of different origins ought to be considered when multiple tumors are present within the pancreas.

摘要

引言

一个孤立器官同时出现原发性肿瘤的情况极为罕见。胰腺小细胞癌很独特，胰腺内同时存在腺癌和小细胞癌的情况十分罕见。

病例介绍

本文报告一名61岁男性，经内镜超声引导下细针穿刺活检确诊为胰腺同步性小细胞癌和腺癌。

结论

该病例提醒我们，同步性胰腺癌很罕见，当胰腺内出现多个肿瘤时，应考虑不同起源的多个原发性恶性肿瘤的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e44/12140606/e4c95719dca5/cro-2025-0018-0001-545467_F05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e44/12140606/328b1a313d30/cro-2025-0018-0001-545467_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e44/12140606/adf4f8a323ff/cro-2025-0018-0001-545467_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e44/12140606/8afeeab0aedf/cro-2025-0018-0001-545467_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e44/12140606/ca1023017ef7/cro-2025-0018-0001-545467_F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e44/12140606/e4c95719dca5/cro-2025-0018-0001-545467_F05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e44/12140606/328b1a313d30/cro-2025-0018-0001-545467_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e44/12140606/adf4f8a323ff/cro-2025-0018-0001-545467_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e44/12140606/8afeeab0aedf/cro-2025-0018-0001-545467_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e44/12140606/ca1023017ef7/cro-2025-0018-0001-545467_F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e44/12140606/e4c95719dca5/cro-2025-0018-0001-545467_F05.jpg

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本文引用的文献

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First reported case of primary small cell cancer of the pancreas with positive TTF-1 tumor marker.首例伴有TTF-1肿瘤标志物阳性的原发性胰腺小细胞癌病例。
Radiol Case Rep. 2024 Sep 6;19(12):5595-5599. doi: 10.1016/j.radcr.2024.08.034. eCollection 2024 Dec.
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Synchronous Pancreatic Masses.同步性胰腺肿块
ACG Case Rep J. 2023 Apr 20;10(4):e01037. doi: 10.14309/crj.0000000000001037. eCollection 2023 Apr.
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Molecular Pathogenesis of Pancreatic Cancer.胰腺癌的分子发病机制
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Autoimmune pancreatitis exhibiting multiple mass lesions.表现为多发肿块性病变的自身免疫性胰腺炎
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Synchronous and metachronous malignant tumours expect the unexpected.同时性和异时性恶性肿瘤总会出现意想不到的情况。
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Adenocarcinoma involving the whole pancreas with multiple pancreatic masses.
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Multiple primary cancers as clues to environmental and heritable causes of cancer and mechanisms of carcinogenesis.多发性原发性癌症作为癌症环境和遗传病因以及致癌机制的线索。
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Multiple primary malignancies: An epidemiological and pedigree analysis of 57 patients with at least three tumours.多重原发性恶性肿瘤：对57例至少患有三种肿瘤患者的流行病学及家系分析
Eur J Surg Oncol. 2001 Apr;27(3):302-13. doi: 10.1053/ejso.2001.1112.