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肾移植后肝脏的病例研究:采用定制的手术及术后方法治疗多囊性疾病

A Case Study of Liver After Kidney Transplantation: Addressing Polycystic Diseases With Tailored Surgical and Postoperative Approaches.

作者信息

Sun Chengjun, Du Yang, Han Ming, Shi Shaojun, Wu Linwei

机构信息

Department of Organ Transplantation, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.

出版信息

Clin Case Rep. 2025 Jun 4;13(6):e70484. doi: 10.1002/ccr3.70484. eCollection 2025 Jun.

DOI:10.1002/ccr3.70484
PMID:40475349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12137191/
Abstract

Polycystic liver disease is a hereditary disease, which is characterized by the presence of multiple cysts within the liver. In this case, we report a patient with multiple cysts in the kidneys and liver, who underwent kidney transplantation in 2019 and then liver transplantation 4 years later. The complexities of performing liver transplantation in a patient with a prior kidney transplant were significant, particularly due to the enlarged liver obscuring critical vascular structures and necessitating careful intraoperative strategies, such as the side-to-side anastomosis or piggyback techniques to ensure venous return and protect the renal graft. One year post-transplant, the patient exhibited stable liver and kidney functions, demonstrating the feasibility of liver transplantation after kidney transplantation from different donor grafts. The surgical technique and perioperative management require careful consideration.

摘要

多囊肝病是一种遗传性疾病,其特征是肝脏内存在多个囊肿。在此,我们报告一例肾脏和肝脏均有多个囊肿的患者,该患者于2019年接受了肾移植,4年后又接受了肝移植。在先前接受过肾移植的患者中进行肝移植的复杂性很高,尤其是因为肝脏肿大模糊了关键血管结构,需要精心的术中策略,如侧侧吻合或背驮式技术,以确保静脉回流并保护肾移植。移植后一年,患者的肝脏和肾脏功能稳定,证明了从不同供体移植物进行肾移植后再进行肝移植的可行性。手术技术和围手术期管理需要仔细考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c19d/12137191/03989356a71b/CCR3-13-e70484-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c19d/12137191/d6001e243271/CCR3-13-e70484-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c19d/12137191/379a45f15869/CCR3-13-e70484-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c19d/12137191/03989356a71b/CCR3-13-e70484-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c19d/12137191/d6001e243271/CCR3-13-e70484-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c19d/12137191/379a45f15869/CCR3-13-e70484-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c19d/12137191/03989356a71b/CCR3-13-e70484-g002.jpg

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本文引用的文献

1
Extrarenal Manifestations: Polycystic Liver Disease and Its Complications.肾外表现:多囊肝疾病及其并发症。
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Combined liver-kidney transplant in polycystic diseases: a case report.多囊病的肝肾联合移植:病例报告。
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Comparison of the modified piggyback with standard piggyback and conventional orthotopic liver transplantation techniques: a network meta-analysis.
改良背驮式与标准背驮式和传统原位肝移植技术的比较:一项网络荟萃分析。
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Porcine Liver Transplantation Without Veno-venous Bypass As an Extended Criteria Donor Model.猪肝移植术,无需静脉-静脉旁路,作为一种扩展标准供体模型。
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Effectiveness of Open Fenestration for Autosomal Dominant Polycystic Liver Disease.开放性开窗术治疗常染色体显性遗传性多囊肝病的疗效
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Acute kidney injury after liver transplantation, perioperative risk factors, and outcome: prospective observational study of 1681 patients (OLTx Study).肝移植术后急性肾损伤、围手术期危险因素和结局:1681 例患者的前瞻性观察研究(OLTx 研究)。
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Crossmatch, Donor-specific Antibody Testing, and Immunosuppression in Simultaneous Liver and Kidney Transplantation: A Review.原位肝肾联合移植中的交叉配型、供者特异性抗体检测和免疫抑制:综述。
Transplantation. 2021 Dec 1;105(12):e285-e291. doi: 10.1097/TP.0000000000003694.
8
A Systematic Review and Meta-Analysis of Machine Perfusion vs. Static Cold Storage of Liver Allografts on Liver Transplantation Outcomes: The Future Direction of Graft Preservation.肝移植中机器灌注与肝脏同种异体移植物静态冷藏对移植结局影响的系统评价和荟萃分析:移植物保存的未来方向
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Laparoscopic hepatic lobectomy for symptomatic polycystic liver disease.腹腔镜肝叶切除术治疗症状性多囊肝病。
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10
Hypothermic machine perfusion reduces the incidences of early allograft dysfunction and biliary complications and improves 1-year graft survival after human liver transplantation: A meta-analysis.低温机器灌注可降低人肝移植后早期移植物功能障碍和胆道并发症的发生率,并提高1年移植物存活率:一项荟萃分析。
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