Kahila Yuval, Barel Maguli S, Bruoha Sharon, Gadon Hadar, Yeshurun Shemesh Efrat M, Lapidus Irina, El Hay Karam Abd, Gluzman Yuri, Star Artyom, Yosefy Chaim, Rubinshtein Ronen, Assali Abid, Haim Moti, Fuchs Shmuel, Lev Eli I, Roguin Ariel
Cardiology Department, Samson Assuta Ashdod Medical Center, Ashdod, Israel, and the Ben-Gurion University of the Negev, Israel.
Cardiology Department, Hillel Yaffe Medical Center, Hadera, Israel, and the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel.
Int J Cardiol Heart Vasc. 2025 May 8;59:101697. doi: 10.1016/j.ijcha.2025.101697. eCollection 2025 Aug.
We aimed to analyze whether national level stressful events were associated with an increase the incidence of Takotsubo syndrome. Takotsubo syndrome is an acute reversible heart failure, characterized by transient regional wall abnormality in the absence of a culprit coronary disease, usually caused by acute stressful etiologies. The terror attack of October 7th 2023 and the subsequent war had an enormous impact on the society in Israel. This was a multi-center, observational, analytic, retrospective, case-control study. To examine our hypothesis, we compared the incidence of Takotsubo syndrome in 7 medical centers in Israel during the period of October-December 2023 ("during war") to the period of October-December 2022 ("before war"), both as an absolute number and as a percentage of all admissions in these 7 medical centers. During the period before the war, 20 patients (0.54 % of all admissions to the cardiology departments) were hospitalized with a proven diagnosis of Takotsubo syndrome, compared with 39 patients (1.07 % of all admissions to the cardiology departments) during the war, accounting for a 95 % increase in the absolute number, and 98 % increase in the percentage of all admissions (p = 0.01, OR = 1.98). Most of the demographic and clinical characteristics, laboratory results, ECG, echocardiogram and angiographic findings were similar between the two groups. Our study showed a significant increase in the incidence of Takotsubo syndrome in Israel during the first three months of the war, suggesting the October 7th terror attack and the consequent war was a traumatic event for the society of Israel.
我们旨在分析国家级应激事件是否与应激性心肌病发病率的增加有关。应激性心肌病是一种急性可逆性心力衰竭，其特征是在无罪犯冠状动脉疾病的情况下出现短暂的局部室壁异常，通常由急性应激因素引起。2023年10月7日的恐怖袭击及随后的战争对以色列社会产生了巨大影响。这是一项多中心、观察性、分析性、回顾性病例对照研究。为检验我们的假设，我们比较了以色列7家医疗中心在2023年10月至12月期间（“战争期间”）与2022年10月至12月期间（“战前”）应激性心肌病的发病率，包括绝对病例数以及占这7家医疗中心所有入院病例的百分比。战前期间，有20例确诊为应激性心肌病的患者住院（占心脏病科所有入院病例的0.54%），而战争期间为39例（占心脏病科所有入院病例的1.07%），绝对病例数增加了95%，占所有入院病例的百分比增加了98%（p = 0.01，OR = 1.98）。两组之间的大多数人口统计学和临床特征、实验室检查结果、心电图、超声心动图和血管造影结果相似。我们的研究表明，战争头三个月以色列应激性心肌病的发病率显著增加，这表明10月7日的恐怖袭击及随之而来的战争对以色列社会来说是一场创伤性事件。
