In this editorial, we comment on the article by Sá-Oliveira . We focus specifically on the role of platelet-rich fibrin (PRF) in modulating innate immunity to enhance wound repair. The process of wound healing is complex and involves a coordinated series of biological events, including inflammation, cell proliferation, and tissue remodeling. The innate immune system is important in the early stages of wound repair, with inflammation being a crucial initial phase in tissue regeneration. However, the inflammatory response should be regulated, as excessive or dysregulated inflammation can impair healing. Platelet concentrates, specifically PRF, have originated as promising tools to optimize the tissue repair process. PRF is a second-generation platelet concentrate, and the release of growth factors (GFs) plays a determining role in several aspects of wound healing, including promoting cell proliferation, stimulating angiogenesis, and modulating inflammation. PRF forms a fibrin matrix that entraps platelets and GFs. This structure allows for their sustained release over time, which is believed to provide a more favorable microenvironment for tissue repair. Recent research by Sá-Oliveira has provided valuable evidence supporting the efficacy of PRF in promoting wound healing. Their study, conducted on an animal model, demonstrated that PRF-based dressings were more effective in accelerating wound closure in the early stages of the healing process, enhancing tissue repair, and modulating the inflammatory response. We explore how PRF's unique properties contribute to a more controlled and effective healing process. By examining these findings, we aim to highlight PRF's potential as a promising therapeutic strategy for improved wound management.