Ghanaati Shahram, Śmieszek-Wilczewska Joanna, Al-Maawi Sarah, Neff Pauline, Zadeh Homayoun H, Sader Robert, Heselich Anja, Rutkowski James L
FORM-Lab, Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.
Department of Dental Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-027 Katowice, Poland.
Bioengineering (Basel). 2022 Nov 8;9(11):661. doi: 10.3390/bioengineering9110661.
Systematic evaluations regarding the influence of PRF in ridge sealing are still lacking. To the best of our knowledge, this is the first systemic randomized, controlled, clinical approach dealing with the potential of a systematic applied solid PRF on soft tissue socket healing of molar and premolar extraction sockets with evaluation for up to 90 days. Qualitative and quantitative image analysis showed that PRF contributed to a significantly faster ridge sealing, within the period of 7-10 days in both tooth types. This led to a visibly less contraction at the PRF-treated group sites at day 90. Patients' pain perception demonstrated no statistic significance between both groups (PRF vs. natural healing), but the patients in PRF group seemed to have had less pain throughout the observational period. It becomes evident that PRF is able to serve as a promotor of the secondary wound healing cascade. The guiding capacity of PRF accelerating the process of open ridge healing makes it possible to act as a natural growth factor drug delivery system, providing a more predictable guided open wound healing of the ridge with less contraction of the soft tissue, the latter being a key factor for the subsequent successful dental implantation and oral rehabilitation.
关于富血小板纤维蛋白（PRF）在牙槽嵴封闭方面影响的系统性评估仍然缺乏。据我们所知，这是首次采用系统性随机对照临床方法，研究系统性应用固体PRF对磨牙和前磨牙拔牙创软组织愈合的影响，并进行长达90天的评估。定性和定量图像分析表明，在7至10天的时间段内，PRF能显著加快两种牙型拔牙创的牙槽嵴封闭。这使得在第90天时，PRF治疗组部位的收缩明显减少。两组患者（PRF组与自然愈合组）的疼痛感知无统计学差异，但PRF组患者在整个观察期内似乎疼痛较轻。显然，PRF能够作为二期伤口愈合级联反应的促进剂。PRF加速开放性牙槽嵴愈合过程的引导能力使其能够作为一种天然生长因子药物递送系统，为牙槽嵴提供更可预测的开放性伤口愈合，减少软组织收缩，而软组织收缩是后续成功进行牙种植和口腔修复的关键因素。
