Li Xu, Hu Lan, Hu Qin, Jin Hua
First School of Clinical Medicine, Anhui University of Chinese Medicine, Hefei, Anhui 230031, P.R. China.
Department of Nephrology, The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, Anhui 230031, P.R. China.
Int J Mol Med. 2025 Aug;56(2). doi: 10.3892/ijmm.2025.5562. Epub 2025 Jun 6.
Lactate, traditionally overlooked as a glycolytic byproduct, has recently been recognized for its significant biological roles. The normal kidney plays an essential role in maintaining systemic glucose and lactate homeostasis. Lactylation, as a new epigenetic modification, influences the initiation and progression of kidney diseases through the regulation of gene transcription and cellular metabolism. The present review summarizes current perspectives on the physiological functions of lactate and its renal metabolism, analyzes the roles of lactate and lactylation in acute kidney injury, diabetic nephropathy and chronic kidney disease, and proposes that targeted modulation of lactate metabolism may represent a promising therapeutic strategy for kidney disorders, thereby providing a foundation for future investigations.
乳酸，传统上被视为糖酵解的副产物而被忽视，最近已因其重要的生物学作用而受到认可。正常肾脏在维持全身葡萄糖和乳酸稳态中起着至关重要的作用。乳酰化作为一种新的表观遗传修饰，通过调节基因转录和细胞代谢影响肾脏疾病的发生和发展。本综述总结了目前关于乳酸的生理功能及其肾脏代谢的观点，分析了乳酸和乳酰化在急性肾损伤、糖尿病肾病和慢性肾病中的作用，并提出靶向调节乳酸代谢可能是肾脏疾病的一种有前景的治疗策略，从而为未来的研究提供基础。
