Luo Yu, Li Xiaolin, Liu Yaling, Wang Xiaodong
Department of Cardiology, Zigong Fourth People's Hospital, Zigong, Sichuan, China.
Department of Rehabilitation Medicine, Jinggangshan University, Health Science Center, Ji'an, China.
Acta Cardiol. 2025 Jul;80(5):506-513. doi: 10.1080/00015385.2025.2515306. Epub 2025 Jun 6.
To investigate the relationship among high sensitive C reactive protein (hs-CRP), interleukin (IL)-6, tumour necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-9, growth differentiation factor (GDF)-15, corrected thrombolysis in myocardial infarction (TIMI) frame count and major adverse cardiovascular events (MACEs) in atherosclerosis coronary artery ectasia (CAE).
One hundred and sixty-five CAE patients were included. All candidates were divided into symptomatic (107) and asymptomatic (58). Serum hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 were detected. Coronary artery blood flow velocity was evaluated by corrected TIMI frame count (CTFC). The relationship among inflammatory marker levels, CTFC, and clinical symptoms was analysed. The MACEs were recorded during a 2-year follow-up.
Symptomatic atherosclerosis CAE manifested male gender, more hypertension, dyslipidemia and smoking than asymptomatic compartments. These patients demonstrated higher serum levels of hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 than those of asymptomatic compartments ( < 0.05, respectively). The CTFC in symptomatic atherosclerosis CAE was lower than that of asymptomatic ones ( < 0.05, respectively). More MACEs occurred in symptomatic than in asymptomatic atherosclerosis CAE during the 2-year follow-up ( < 0.01).
Male gender, hypertension, dyslipidemia and smoking are more frequent in symptomatic atherosclerosis CAE. Hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 have a positive correlation with symptoms and CTFC in atherosclerosis CAE and are predictors of MACEs during 2-year follow-up.
探讨高敏C反应蛋白（hs-CRP）、白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α、基质金属蛋白酶（MMP）-9、生长分化因子（GDF）-15、校正的心肌梗死溶栓（TIMI）帧数与动脉粥样硬化性冠状动脉扩张（CAE）患者主要不良心血管事件（MACE）之间的关系。
纳入165例CAE患者。所有入选者分为有症状组（107例）和无症状组（58例）。检测血清hs-CRP、IL-6、TNF-α、MMP-9和GDF-15。通过校正的TIMI帧数（CTFC）评估冠状动脉血流速度。分析炎症标志物水平、CTFC与临床症状之间的关系。在2年随访期间记录MACE。
有症状的动脉粥样硬化性CAE患者在男性、高血压、血脂异常和吸烟方面比无症状组更常见。这些患者的血清hs-CRP、IL-6、TNF-α、MMP-9和GDF-15水平高于无症状组（均P<0.05）。有症状的动脉粥样硬化性CAE患者的CTFC低于无症状患者（均P<0.05）。在2年随访期间，有症状的动脉粥样硬化性CAE患者发生的MACE比无症状患者更多（P<0.01）。
有症状的动脉粥样硬化性CAE患者中男性、高血压、血脂异常和吸烟更为常见。hs-CRP、IL-6、TNF-α、MMP-9和GDF-15与动脉粥样硬化性CAE的症状和CTFC呈正相关，并且是2年随访期间MACE的预测指标。
