Sagebiel R W
Pathology. 1985 Apr;17(2):285-90. doi: 10.3109/00313028509063769.
The histopathology of melanocytic proliferations in human skin can be defined in a way which allows a rational approach to their management. Early and/or premalignant lesions such as melanocytic hypertrophy, hyperplasia, dysplasia, and atypical hyperplasias are correlated with clinical lesions such as lentigo, compound nevoid lentigo, changes in nevi during pregnancy, and unusual moles seen in patients with the dysplastic nevus syndrome. Clinical management of such lesions may be determined from the pathological process. Hypertrophic and hyperplastic lesions need not be re-excised, although partially removed moles showing junctional hyperplasia may recur clinically. The mildly and moderately dysplastic nevus need only be narrowly removed. Severe dysplasia and melanoma in situ may recur locally as invasive melanoma, and consideration for conservative reexcision is warranted. Dysplastic nevi should be considered to be markers of patients who may develop melanoma. Patients with dysplastic nevi or a family history of unusual moles or melanoma should have continued follow-up, preferably with standardized clinical photographs.
人类皮肤黑素细胞增生性病变的组织病理学可以通过一种方式来定义，这种方式能够为其管理提供合理的方法。早期和/或癌前病变，如黑素细胞肥大、增生、发育异常和非典型增生，与临床病变相关，如雀斑样痣、复合痣样雀斑样痣、孕期痣的变化以及发育异常痣综合征患者出现的异常痣。此类病变的临床管理可根据病理过程来确定。肥大性和增生性病变无需再次切除，尽管部分切除且显示交界性增生的痣可能会在临床上复发。轻度和中度发育异常痣只需进行窄切。重度发育异常和原位黑素瘤可能会作为浸润性黑素瘤局部复发，因此有必要考虑进行保守性再次切除。发育异常痣应被视为可能发生黑素瘤的患者的标志物。有发育异常痣或有异常痣或黑素瘤家族史的患者应持续接受随访，最好拍摄标准化临床照片。
