The prosed study aims to provide COVID-19 critical success factors (CSF) associated with pandemic circumstances in the Indian healthcare industry (HCI). The CSF was identified via expert team inputs and a detailed literature review. The Decision-Making Trial and Evaluation Laboratory (DEMATEL) method is used to determine the causal relationship between identified CSF. The methodology was supported by the case study of the Indian HCI. A total of 15 CSF in the Indian HCI during COVID-19 are identified and prioritized using the DEMATEL method. The findings indicate that the high-quality personal protective equipment (PPEs; LC8) and testing laboratories/facilities, centres, and kits (LC15) are the significant cause, and appropriate healthcare laws (LC13) are the least effect group. The study shows that policy and decision-makers need to emphasize on LC8 and LC15 CSF in the Indian HCI and act accordingly to win the battle against post-COVID-19 circumstance. The policy/decision-makers and healthcare administrations can identify the CSF and focus on that particular CSF. The identified CSF will help policy and decision-makers swiftly build up the HCI to cope with the future pandemic.