Boyne L J, Kerzner B, McClung H J
Pediatrics. 1985 Oct;76(4):557-61.
Eighteen children with chronic, nonspecific diarrhea were evaluated prospectively to determine "basal" fat consumption and the response of their diarrhea to diets containing either 25% or 50% of total calories as fat. In the observation period, prior to initiating any alteration in dietary fat content, diarrhea subsided. Only five of the 18 patients had a low fat intake (less than 27% of total calories) at the outset of the study, and spontaneous resolution of the diarrhea precluded an assessment of the effect of altering fat intake on stool frequency. We are, therefore, impressed that a preliminary observation period, in which details of the diarrhea are documented, is essential to evaluate any treatment modality for this poorly defined condition.
对18名患有慢性非特异性腹泻的儿童进行了前瞻性评估，以确定“基础”脂肪摄入量，以及他们的腹泻对脂肪占总热量25%或50%的饮食的反应。在观察期内，在开始改变饮食脂肪含量之前，腹泻就已缓解。在研究开始时，18名患者中只有5人的脂肪摄入量较低（低于总热量的27%），腹泻的自发缓解使得无法评估改变脂肪摄入量对大便频率的影响。因此，我们深刻认识到，记录腹泻细节的初步观察期对于评估这种定义不明确的疾病的任何治疗方式至关重要。
